7UZP

parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing three beta-amino acids

Summary for 7UZP

Entry DOI	10.2210/pdb7uzp/pdb
Descriptor	Parathyroid hormone/parathyroid hormone-related peptide receptor, PTHrP[1-36] 24,28,31 XCP, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	parathyroid hormone 1 receptor, signaling, beta-amino acid, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	44514.04
Authors	Yu, Z.,Bruchs, A.T.,Bingman, C.A.,Gellman, S.H. (deposition date: 2022-05-09, release date: 2022-10-19, Last modification date: 2024-02-28)
Primary citation	Liu, S.,Yu, Z.,Daley, E.J.,Bingman, C.A.,Bruchs, A.T.,Gardella, T.J.,Gellman, S.H. Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo. Proc.Natl.Acad.Sci.USA, 119:e2212736119-e2212736119, 2022 Cited by PubMed: 36409914 DOI: 10.1073/pnas.2212736119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation