7TA3
Trimer-to-Monomer Disruption of Tumor Necrosis Factor-alpha (TNF-alpha) by alpha-peptide-3
Summary for 7TA3
Entry DOI | 10.2210/pdb7ta3/pdb |
Descriptor | Alpha-peptide-3, Tumor necrosis factor (3 entities in total) |
Functional Keywords | tumor necrosis factor-alpha, signaling, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 42123.51 |
Authors | Niu, J.,Bingman, C.A.,Gellman, S.H. (deposition date: 2021-12-20, release date: 2022-06-29, Last modification date: 2024-04-03) |
Primary citation | Niu, J.,Cederstrand, A.J.,Eddinger, G.A.,Yin, B.,Checco, J.W.,Bingman, C.A.,Outlaw, V.K.,Gellman, S.H. Trimer-to-Monomer Disruption Mechanism for a Potent, Protease-Resistant Antagonist of Tumor Necrosis Factor-alpha Signaling. J.Am.Chem.Soc., 144:9610-9617, 2022 Cited by PubMed: 35613436DOI: 10.1021/jacs.1c13717 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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