7UZO
Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing one beta-amino acid
Summary for 7UZO
| Entry DOI | 10.2210/pdb7uzo/pdb |
| Descriptor | Parathyroid hormone/parathyroid hormone-related peptide receptor, Peptide from Parathyroid hormone-related protein, ZINC ION, ... (4 entities in total) |
| Functional Keywords | parathyroid hormone 1 receptor, signaling, beta-amino acid, signaling protein |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 14670.14 |
| Authors | Yu, Z.,Bruchs, A.T.,Bingman, C.A.,Gellman, S.H. (deposition date: 2022-05-09, release date: 2022-10-19, Last modification date: 2023-11-15) |
| Primary citation | Liu, S.,Yu, Z.,Daley, E.J.,Bingman, C.A.,Bruchs, A.T.,Gardella, T.J.,Gellman, S.H. Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo. Proc.Natl.Acad.Sci.USA, 119:e2212736119-e2212736119, 2022 Cited by PubMed: 36409914DOI: 10.1073/pnas.2212736119 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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