4JG0
 
 | | Structure of phosphoserine/threonine (pSTAb) scaffold bound to pSer peptide | | 分子名称: | Fab heavy chain, Fab light chain, PROPANOIC ACID, ... | | 著者 | Koerber, J.T, Thomsen, N.D, Hannigan, B.T, Degrado, W.F, Wells, J.A. | | 登録日 | 2013-02-28 | | 公開日 | 2013-08-28 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
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4JFZ
 | | Structure of phosphoserine (pSAb) scaffold bound to pSer peptide | | 分子名称: | Fab heavy chain, Fab light chain, PROPANOIC ACID, ... | | 著者 | Koerber, J.T, Thomsen, N.D, Hannigan, B.T, Degrado, W.F, Wells, J.A. | | 登録日 | 2013-02-28 | | 公開日 | 2013-08-28 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
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4JG1
 | | Structure of phosphoserine/threonine (pSTAb) scaffold bound to pThr peptide | | 分子名称: | Fab heavy chain, Fab light chain, PROPANOIC ACID, ... | | 著者 | Koerber, J.T, Thomsen, N.D, Hannigan, B.T, Degrado, W.F, Wells, J.A. | | 登録日 | 2013-02-28 | | 公開日 | 2013-08-28 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
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4JFY
 | | Apo structure of phosphotyrosine (pYAb) scaffold | | 分子名称: | Fab heavy chain, Fab light chain, TETRAETHYLENE GLYCOL | | 著者 | Koerber, J.T, Thomsen, N.D, Hannigan, B.T, Degrado, W.F, Wells, J.A. | | 登録日 | 2013-02-28 | | 公開日 | 2013-08-28 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | | 主引用文献 | Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
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4JFX
 | | Structure of phosphotyrosine (pTyr) scaffold bound to pTyr peptide | | 分子名称: | Fab heavy chain, Fab light chain, Phosphopeptide, ... | | 著者 | Koerber, J.T, Thomsen, N.D, Hannigan, B.T, Degrado, W.F, Wells, J.A. | | 登録日 | 2013-02-28 | | 公開日 | 2013-09-25 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
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8EW6
 | | Anti-human CD8 VHH complex with CD8 alpha | | 分子名称: | Anti-CD8 alpha VHH, T-cell surface glycoprotein CD8 alpha chain | | 著者 | Kiefer, J.R, Williams, S, Davies, C.W, Koerber, J.T, Sriraman, S.K, Yin, Y.P. | | 登録日 | 2022-10-21 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-02-01 | | 実験手法 | X-RAY DIFFRACTION (1.904 Å) | | 主引用文献 | Development of an 18 F-labeled anti-human CD8 VHH for same-day immunoPET imaging.
Eur J Nucl Med Mol Imaging, 50, 2023
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2I80
 | | Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies | | 分子名称: | 3-CHLORO-2,2-DIMETHYL-N-[4-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE, D-alanine-D-alanine ligase | | 著者 | Liu, S, Chang, J.S, Herberg, J.T, Horng, M.-M, Tomich, P.K, Lin, A.H, Marotti, K.R. | | 登録日 | 2006-08-31 | | 公開日 | 2006-09-26 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2I8C
 | | Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, D-alanine-D-alanine ligase, MAGNESIUM ION, ... | | 著者 | Liu, S, Chang, J.S, Herberg, J.T, Horng, M, Tomich, P.K, Lin, A.H, Marotti, K.R. | | 登録日 | 2006-09-01 | | 公開日 | 2006-09-26 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2I87
 | | Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies | | 分子名称: | D-alanine-D-alanine ligase, SULFATE ION | | 著者 | Liu, S, Chang, J.S, Herberg, J.T, Horng, M, Tomich, P.K, Lin, A.H, Marotti, K.R. | | 登録日 | 2006-09-01 | | 公開日 | 2006-10-03 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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7U8G
 | | Cryo-EM structure of the core human NADPH oxidase NOX2 | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 7G5 - heavy chain, ... | | 著者 | Noreng, S, Ota, N, Sun, Y, Masureel, M, Payandeh, J, Yi, T, Koerber, J.T. | | 登録日 | 2022-03-08 | | 公開日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structure of the core human NADPH oxidase NOX2.
Nat Commun, 13, 2022
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6VVU
 | | Anti-Tryptase fab E104.v1 bound to tryptase | | 分子名称: | CALCIUM ION, Fab E104.v1 heavy chain, Fab E104.v1 light chain, ... | | 著者 | Ultsch, M, Koerber, J.T. | | 登録日 | 2020-02-18 | | 公開日 | 2020-12-30 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Bivalent antibody pliers inhibit beta-tryptase by an allosteric mechanism dependent on the IgG hinge.
Nat Commun, 11, 2020
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1HSK
 | | CRYSTAL STRUCTURE OF S. AUREUS MURB | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE | | 著者 | Benson, T.E, Harris, M.S, Choi, G.H, Cialdella, J.I, Herberg, J.T, Martin Jr, J.P, Baldwin, E.T. | | 登録日 | 2000-12-27 | | 公開日 | 2001-03-14 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A structural variation for MurB: X-ray crystal structure of Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB).
Biochemistry, 40, 2001
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6ESQ
 | | Structure of the acetoacetyl-CoA thiolase/HMG-CoA synthase complex from Methanothermococcus thermolithotrophicus soaked with acetyl-CoA | | 分子名称: | CHLORIDE ION, COENZYME A, HydroxyMethylGlutaryl-CoA synthase, ... | | 著者 | Voegeli, B, Engilberge, S, Girard, E, Riobe, F, Maury, O, Erb, J.T, Shima, S, Wagner, T. | | 登録日 | 2017-10-24 | | 公開日 | 2018-03-14 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7U5B
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7MFR
 | | Crystal Structure of a Fab fragment bound to peptide GGM | | 分子名称: | Antibody fragment - Heavy Chain of fab, Antibody fragment - Light Chain of fab, GLY-GLY-MET, ... | | 著者 | Sudhamsu, J. | | 登録日 | 2021-04-10 | | 公開日 | 2021-06-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.848 Å) | | 主引用文献 | Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W.
Nat Commun, 12, 2021
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7MDP
 | | KRas G12C in complex with G-2897 | | 分子名称: | 1,2-ETHANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, 4-(trifluoromethyl)-1,3-benzothiazol-2-amine, ... | | 著者 | Oh, A, Frank, Y, Wang, W. | | 登録日 | 2021-04-05 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Nat.Biotechnol., 40, 2022
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7RP3
 | | Crystal structure of GNE-1952 alkylated KRAS G12C in complex with 2H11 CLAMP | | 分子名称: | 1,2-ETHANEDIOL, 1-[4-[6-chloranyl-7-(5-methyl-1~{H}-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl]propan-1-one, GLYCEROL, ... | | 著者 | Oh, A, Tam, C, Wang, W. | | 登録日 | 2021-08-03 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Nat.Biotechnol., 40, 2022
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7RP2
 | | Crystal structure of Kas G12C in complex with 2H11 CLAMP | | 分子名称: | 1,2-ETHANEDIOL, CACODYLATE ION, GTPase KRas, ... | | 著者 | Oh, A, Tam, C, Wang, W. | | 登録日 | 2021-08-03 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Nat.Biotechnol., 40, 2022
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7RP4
 | | Crystal structure of KRAS G12C in complex with GNE-1952 | | 分子名称: | 1-[4-[6-chloranyl-7-(5-methyl-1~{H}-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl]propan-1-one, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Oh, A, Tam, C, Wang, W. | | 登録日 | 2021-08-03 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Nat.Biotechnol., 40, 2022
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8TLM
 | | Structure of a class A GPCR/Fab complex | | 分子名称: | C-C chemokine receptor type 8, Green fluorescent protein fusion, Fab heavy chain, ... | | 著者 | Sun, D, Johnson, M, Masureel, M. | | 登録日 | 2023-07-27 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8.
Nat Commun, 14, 2023
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8U1U
 | | Structure of a class A GPCR/agonist complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C-C motif chemokine 1,C-C chemokine receptor type 8,EGFP fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Sun, D, Johnson, M, Masureel, M. | | 登録日 | 2023-09-02 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8.
Nat Commun, 14, 2023
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6O1F
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6VJA
 | | Structure of CD20 in complex with rituximab Fab | | 分子名称: | B-lymphocyte antigen CD20, CHOLESTEROL HEMISUCCINATE, Rituximab Fab heavy chain, ... | | 著者 | Rohou, A, Croll, T.I. | | 登録日 | 2020-01-15 | | 公開日 | 2020-02-26 | | 最終更新日 | 2020-03-25 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab.
Science, 367, 2020
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4JR2
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4JQY
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