8EW6

Anti-human CD8 VHH complex with CD8 alpha

Summary for 8EW6

• Entry DOI: 10.2210/pdb8ew6/pdb
• Related: 7UVF
• Descriptor: T-cell surface glycoprotein CD8 alpha chain, Anti-CD8 alpha VHH (3 entities in total)
• Functional Keywords: immune system, cd8a, vhh, pet imaging
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 29581.92

Authors

Kiefer, J.R.,Williams, S.,Davies, C.W.,Koerber, J.T.,Sriraman, S.K.,Yin, Y.P. (deposition date: 2022-10-21, release date: 2022-11-23, Last modification date: 2024-11-13)

Primary citation

Sriraman, S.K.,Davies, C.W.,Gill, H.,Kiefer, J.R.,Yin, J.,Ogasawara, A.,Urrutia, A.,Javinal, V.,Lin, Z.,Seshasayee, D.,Abraham, R.,Haas, P.,Koth, C.,Marik, J.,Koerber, J.T.,Williams, S.P.
Development of an 18 F-labeled anti-human CD8 VHH for same-day immunoPET imaging.
Eur J Nucl Med Mol Imaging, 50:679-691, 2023

PubMed Abstract: Cancer immunotherapies (CITs) have revolutionized the treatment of certain cancers, but many patients fail to respond or relapse from current therapies, prompting the need for new CIT agents. CD8 T cells play a central role in the activity of many CITs, and thus, the rapid imaging of CD8 cells could provide a critical biomarker for new CIT agents. However, existing Zr-labeled CD8 PET imaging reagents exhibit a long circulatory half-life and high radiation burden that limit potential applications such as same-day and longitudinal imaging.

PubMed: 36346438
DOI: 10.1007/s00259-022-05998-0

Experimental method

X-RAY DIFFRACTION (1.904 Å)