7RP4

Crystal structure of KRAS G12C in complex with GNE-1952

Summary for 7RP4

• Entry DOI: 10.2210/pdb7rp4/pdb
• Descriptor: Isoform 2B of GTPase KRas, 1-[4-[6-chloranyl-7-(5-methyl-1~{H}-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: gtpase, inhibitor, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 40514.28

Authors

Oh, A.,Tam, C.,Wang, W. (deposition date: 2021-08-03, release date: 2022-03-16, Last modification date: 2023-10-18)

• Primary citation: Davies, C.W.,Oh, A.J.,Mroue, R.,Steffek, M.,Bruning, J.M.,Xiao, Y.,Feng, S.,Jayakar, S.,Chan, E.,Arumugam, V.,Uribe, S.C.,Drummond, J.,Frommlet, A.,Lu, C.,Franke, Y.,Merchant, M.,Koeppen, H.,Quinn, J.G.,Malhotra, S.,Do, S.,Gazzard, L.,Purkey, H.E.,Rudolph, J.,Mulvihill, M.M.,Koerber, J.T.,Wang, W.,Evangelista, M.; Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.; Nat.Biotechnol., 40:769-778, 2022; PubMed: 34992247; DOI: 10.1038/s41587-021-01126-9

Experimental method

X-RAY DIFFRACTION (2.15 Å)