7U5B
Structure of Human KLK5 bound to anti-KLK5 Fab
Summary for 7U5B
Entry DOI | 10.2210/pdb7u5b/pdb |
Descriptor | anti-KLK5 Fab Heavy Chain, anti-KLK5 Fab Light Chain, Kallikrein-5, ... (5 entities in total) |
Functional Keywords | protease, kallikrien, klk5, hydrolase, hydrolase-immune system complex, hydrolase/immune system |
Biological source | synthetic construct More |
Total number of polymer chains | 6 |
Total formula weight | 145873.05 |
Authors | Yin, J.,Sudhamsu, J. (deposition date: 2022-03-02, release date: 2022-12-14, Last modification date: 2023-10-25) |
Primary citation | Chavarria-Smith, J.,Chiu, C.P.C.,Jackman, J.K.,Yin, J.,Zhang, J.,Hackney, J.A.,Lin, W.Y.,Tyagi, T.,Sun, Y.,Tao, J.,Dunlap, D.,Morton, W.D.,Ghodge, S.V.,Maun, H.R.,Li, H.,Hernandez-Barry, H.,Loyet, K.M.,Chen, E.,Liu, J.,Tam, C.,Yaspan, B.L.,Cai, H.,Balazs, M.,Arron, J.R.,Li, J.,Wittwer, A.J.,Pappu, R.,Austin, C.D.,Lee, W.P.,Lazarus, R.A.,Sudhamsu, J.,Koerber, J.T.,Yi, T. Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis. Sci Transl Med, 14:eabp9159-eabp9159, 2022 Cited by PubMed: 36516271DOI: 10.1126/scitranslmed.abp9159 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.371 Å) |
Structure validation
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