7U5B

Structure of Human KLK5 bound to anti-KLK5 Fab

Summary for 7U5B

• Entry DOI: 10.2210/pdb7u5b/pdb
• Descriptor: anti-KLK5 Fab Heavy Chain, anti-KLK5 Fab Light Chain, Kallikrein-5, ... (5 entities in total)
• Functional Keywords: protease, kallikrien, klk5, hydrolase, hydrolase-immune system complex, hydrolase/immune system
• Biological source: synthetic construct; More
• Total number of polymer chains: 6
• Total formula weight: 145873.05

Authors

Yin, J.,Sudhamsu, J. (deposition date: 2022-03-02, release date: 2022-12-14, Last modification date: 2023-10-25)

• Primary citation: Chavarria-Smith, J.,Chiu, C.P.C.,Jackman, J.K.,Yin, J.,Zhang, J.,Hackney, J.A.,Lin, W.Y.,Tyagi, T.,Sun, Y.,Tao, J.,Dunlap, D.,Morton, W.D.,Ghodge, S.V.,Maun, H.R.,Li, H.,Hernandez-Barry, H.,Loyet, K.M.,Chen, E.,Liu, J.,Tam, C.,Yaspan, B.L.,Cai, H.,Balazs, M.,Arron, J.R.,Li, J.,Wittwer, A.J.,Pappu, R.,Austin, C.D.,Lee, W.P.,Lazarus, R.A.,Sudhamsu, J.,Koerber, J.T.,Yi, T.; Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis.; Sci Transl Med, 14:eabp9159-eabp9159, 2022; PubMed: 36516271; DOI: 10.1126/scitranslmed.abp9159

Experimental method

X-RAY DIFFRACTION (2.371 Å)