8C58
| CpG specific M.MpeI methyltransferase crystallized in the presence of 5-hydroxycytosine and 5-methylcytosine containing dsDNA | 分子名称: | CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5OC)P*GP*CP*TP*GP*AP*A)-3'), ... | 著者 | Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. | 登録日 | 2023-01-06 | 公開日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
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8C57
| CpG specific M.MpeI methyltransferase crystallized in the presence of 5,6-dihydro-5-azacytosine (converted to 5m-dhaC) and 5-methylcytosine containing dsDNA | 分子名称: | CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5MA)P*GP*CP*TP*GP*AP*A)-3'), ... | 著者 | Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. | 登録日 | 2023-01-06 | 公開日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
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8C56
| CpG specific M.MpeI methyltransferase crystallized in the presence of 2'-deoxy-5-methylzebularine (5mZ) and 5-methylcytosine containing dsDNA | 分子名称: | Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5PY)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ... | 著者 | Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. | 登録日 | 2023-01-06 | 公開日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
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8C59
| CpG specific M.MpeI methyltransferase crystallized in the presence of 5-bromocytosine (converted to 5mC) and 5-methylcytosine containing dsDNA | 分子名称: | CARBONATE ION, CITRIC ACID, Cytosine-specific methyltransferase, ... | 著者 | Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. | 登録日 | 2023-01-06 | 公開日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
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8EIK
| Cryo-EM structure of human DNMT3B homo-hexamer | 分子名称: | DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | 著者 | Lu, J.W, Song, J.K. | 登録日 | 2022-09-15 | 公開日 | 2023-09-20 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
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8EII
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8EIH
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8EIJ
| Cryo-EM structure of human DNMT3B homo-trimer | 分子名称: | DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | 著者 | Lu, J.W, Song, J.K. | 登録日 | 2022-09-15 | 公開日 | 2023-09-20 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
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7C01
| Molecular basis for a potent human neutralizing antibody targeting SARS-CoV-2 RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CB6 heavy chain, CB6 light chain, ... | 著者 | Shi, R, Qi, J, Wang, Q, Gao, F.G, Yan, J. | 登録日 | 2020-04-29 | 公開日 | 2020-05-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. Nature, 584, 2020
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7LO8
| NorA in complex with Fab36 | 分子名称: | Fab36 Heavy Chain, Fab36 Light Chain, Quinolone resistance protein NorA | 著者 | Brawley, D.N, Sauer, D.B, Song, J.M, Koide, A, Koide, S, Traaseth, N.J, Wang, D.N. | 登録日 | 2021-02-09 | 公開日 | 2022-04-20 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus. Nat.Chem.Biol., 18, 2022
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7LO7
| NorA in complex with Fab25 | 分子名称: | Fab25 Heavy Chain, Fab25 Light Chain, Quinolone resistance protein NorA | 著者 | Brawley, D.N, Sauer, D.B, Song, J.M, Koide, A, Koide, S, Traaseth, N.J, Wang, D.N. | 登録日 | 2021-02-09 | 公開日 | 2022-04-20 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | 主引用文献 | Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus. Nat.Chem.Biol., 18, 2022
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3GXU
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6AGO
| Crystal structure of MRG15-ASH1L Histone methyltransferase complex | 分子名称: | Histone-lysine N-methyltransferase ASH1L, Mortality factor 4 like 1, S-ADENOSYLMETHIONINE, ... | 著者 | Lee, Y, Song, J. | 登録日 | 2018-08-13 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.103 Å) | 主引用文献 | Structural Basis of MRG15-Mediated Activation of the ASH1L Histone Methyltransferase by Releasing an Autoinhibitory Loop. Structure, 27, 2019
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6WW5
| Structure of VcINDY-Na-Fab84 in nanodisc | 分子名称: | 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, DASS family sodium-coupled anion symporter, Fab84 Heavy Chain, ... | 著者 | Sauer, D.B, Marden, J, Song, J.M, Koide, A, Koide, S, Wang, D.N. | 登録日 | 2020-05-07 | 公開日 | 2020-09-16 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Structural basis for the reaction cycle of DASS dicarboxylate transporters. Elife, 9, 2020
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5WG3
| Human GRK2 in complex with Gbetagamma subunits and CCG258748 | 分子名称: | 2-fluoro-5-[(3S,4R)-3-{[(1H-indazol-5-yl)oxy]methyl}piperidin-4-yl]-N-[(1H-pyrazol-3-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Bouley, R, Tesmer, J.J.G. | 登録日 | 2017-07-13 | 公開日 | 2017-12-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.896 Å) | 主引用文献 | Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol. Pharmacol., 92, 2017
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4WNK
| Crystal Structure of Bovine G Protein Coupled-Receptor Kinase 5 in Complex with CCG215022 | 分子名称: | (4S)-4-{4-fluoro-3-[(pyridin-2-ylmethyl)carbamoyl]phenyl}-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, G protein-coupled receptor kinase 5, SULFATE ION | 著者 | Homan, K.T, Tesmer, J.J.G. | 登録日 | 2014-10-13 | 公開日 | 2015-06-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor. J.Biol.Chem., 290, 2015
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3CKH
| Crystal structure of Eph A4 receptor | 分子名称: | Ephrin type-A receptor 4 | 著者 | Shi, J.H, Song, J.X. | 登録日 | 2008-03-15 | 公開日 | 2008-09-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor. J.Biol.Chem., 283, 2008
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8ETM
| Human triacylglycerol synthesizing enzyme DGAT1 in complex with DGAT1IN1 inhibitor | 分子名称: | Diacylglycerol O-acyltransferase 1, [(1S,4r)-4-{4-[(4S)-2-({[4-(trifluoromethoxy)phenyl]methyl}carbamoyl)imidazo[1,2-a]pyridin-6-yl]phenyl}cyclohexyl]acetic acid | 著者 | Sui, X, Kun, W, Walther, T, Farese, R, Liao, M. | 登録日 | 2022-10-17 | 公開日 | 2023-06-07 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14, 2023
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8ESM
| Human triacylglycerol synthesizing enzyme DGAT1 in complex with T863 inhibitor | 分子名称: | Diacylglycerol O-acyltransferase 1, {(1r,4r)-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl}acetic acid | 著者 | Sui, X, Kun, W, Walther, T, Farese, R, Liao, M. | 登録日 | 2022-10-14 | 公開日 | 2023-06-07 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14, 2023
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7T9F
| Structure of VcINDY-apo | 分子名称: | DASS family sodium-coupled anion symporter | 著者 | Sauer, D.B, Marden, J.J, Song, J.M, Wang, D.N. | 登録日 | 2021-12-19 | 公開日 | 2022-05-25 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural basis of ion - substrate coupling in the Na + -dependent dicarboxylate transporter VcINDY. Nat Commun, 13, 2022
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7T9G
| Structure of VcINDY-Na+ | 分子名称: | DASS family sodium-coupled anion symporter, SODIUM ION | 著者 | Sauer, D.B, Marden, J.J, Song, J.M, Wang, D.N. | 登録日 | 2021-12-19 | 公開日 | 2022-05-25 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Structural basis of ion - substrate coupling in the Na + -dependent dicarboxylate transporter VcINDY. Nat Commun, 13, 2022
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3FHQ
| Structure of endo-beta-N-acetylglucosaminidase A | 分子名称: | 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, Endo-beta-N-acetylglucosaminidase, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose | 著者 | Jie, Y, Li, L, Shaw, N, Li, Y, Song, J, Zhang, W, Xia, C, Zhang, R, Joachimiak, A, Zhang, H.-C, Wang, L.-X, Wang, P, Liu, Z.-J. | 登録日 | 2008-12-10 | 公開日 | 2009-05-05 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.452 Å) | 主引用文献 | Structural basis and catalytic mechanism for the dual functional endo-beta-N-acetylglucosaminidase A Plos One, 4, 2009
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6WCZ
| CryoEM structure of full-length ZIKV NS5-hSTAT2 complex | 分子名称: | Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION | 著者 | Boxiao, W, Stephanie, T, Kang, Z, Maria, T.S, Jian, F, Jiuwei, L, Linfeng, G, Wendan, R, Yanxiang, C, Ethan, C.V, HeaJin, H, Matthew, J.E, Sean, E.O, Adolfo, G.S, Hong, Z, Rong, H, Jikui, S. | 登録日 | 2020-03-31 | 公開日 | 2020-07-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis for STAT2 suppression by flavivirus NS5. Nat.Struct.Mol.Biol., 27, 2020
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6RMH
| The Rigid-body refined model of the normal Huntingtin. | 分子名称: | Huntingtin | 著者 | Jung, T, Tamo, G, Dal Perraro, M, Hebert, H, Song, J. | 登録日 | 2019-05-06 | 公開日 | 2020-06-03 | 最終更新日 | 2020-12-16 | 実験手法 | ELECTRON MICROSCOPY (9.6 Å) | 主引用文献 | The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain. Structure, 28, 2020
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5KBW
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