8SSU
 
 | | ZnFs 3-11 of CCCTC-binding factor (CTCF) Complexed with 19mer DNA | | 分子名称: | 1,2-ETHANEDIOL, DNA (19-MER) Strand I, DNA (19-MER) Strand II, ... | | 著者 | Horton, J.R, Yang, J, Cheng, X. | | 登録日 | 2023-05-08 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Structures of CTCF-DNA complexes including all 11 zinc fingers.
Nucleic Acids Res., 51, 2023
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8SSR
 | | ZnFs 3-11 of CCCTC-binding factor (CTCF) Complexed with 35mer DNA 35-20 | | 分子名称: | DNA (35-MER) Strand I, DNA (35-MER) Strand II, SODIUM ION, ... | | 著者 | Horton, J.R, Yang, J, Cheng, X. | | 登録日 | 2023-05-08 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.14 Å) | | 主引用文献 | Structures of CTCF-DNA complexes including all 11 zinc fingers.
Nucleic Acids Res., 51, 2023
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8SSQ
 | | ZnFs 3-11 of CCCTC-binding factor (CTCF) Complexed with 35mer DNA 35-4 | | 分子名称: | DNA (35-MER) Strand 2, DNA (35-MER) Strand I, SODIUM ION, ... | | 著者 | Horton, J.R, Yang, J, Cheng, X. | | 登録日 | 2023-05-08 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | | 主引用文献 | Structures of CTCF-DNA complexes including all 11 zinc fingers.
Nucleic Acids Res., 51, 2023
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8SSS
 | | ZnFs 1-7 of CCCTC-binding factor (CTCF) Complexed with 23mer | | 分子名称: | 1,2-ETHANEDIOL, DNA Strand (23mer) I, DNA Strand (23mer) II, ... | | 著者 | Horton, J.R, Yang, J, Cheng, X. | | 登録日 | 2023-05-08 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structures of CTCF-DNA complexes including all 11 zinc fingers.
Nucleic Acids Res., 51, 2023
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2PUY
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2NOG
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8CXZ
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor N6-(3-Phenylpropyl)adenosine (Compound 14) | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*TP*GP*GP*GP*AP*CP*TP*TP*TP*TP*TP*GP*A)-3'), N-(3-phenylpropyl)adenosine, ... | | 著者 | Zhou, J, Horton, J.R, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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8CY1
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 19 | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*TP*GP*GP*GP*AP*CP*TP*TP*TP*TP*TP*GP*A)-3'), N-(5-phenylpentyl)adenosine, ... | | 著者 | Zhou, J, Horton, J.R, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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8CXV
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 3 | | 分子名称: | 1,2-ETHANEDIOL, DNA Strand 1, DNA Strand 2, ... | | 著者 | Horton, J.R, Zhou, J, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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8CXW
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor piclidenoson (Compound 4) | | 分子名称: | 1,2-ETHANEDIOL, DNA Strand 1, DNA Strand 2, ... | | 著者 | Horton, J.R, Zhou, J, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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8CXU
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 2 | | 分子名称: | 1,2-ETHANEDIOL, DNA Strand 1, DNA Strand 2, ... | | 著者 | Horton, J.R, Zhou, J, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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8CXX
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 6 | | 分子名称: | 1,2-ETHANEDIOL, DNA Strand 1, DNA Strand 2, ... | | 著者 | Horton, J.R, Zhou, J, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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8CXT
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor N6-benzyladenosine (Compound 1) | | 分子名称: | 1,2-ETHANEDIOL, DNA Strand 1, DNA Strand 2, ... | | 著者 | Horton, J.R, Zhou, J, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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8CY4
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 16 | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*TP*GP*GP*GP*AP*CP*TP*TP*TP*TP*TP*GP*A)-3'), N-[3-(4-hydroxyphenyl)propyl]adenosine, ... | | 著者 | Zhou, J, Horton, J.R, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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8CY3
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 15 | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*TP*TP*CP*AP*AP*AP*AP*AP*GP*TP*CP*CP*CP*A)-3'), N-[3-(4-aminophenyl)propyl]adenosine, ... | | 著者 | Zhou, J, Horton, J.R, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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8CXS
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor MTA | | 分子名称: | 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, DNA Strand 1, ... | | 著者 | Horton, J.R, Zhou, J, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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8CY0
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor MC4756 (Compound 178) | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*TP*GP*GP*GP*AP*CP*TP*TP*TP*TP*TP*GP*A)-3'), N-(4-phenylbutyl)adenosine, ... | | 著者 | Zhou, J, Horton, J.R, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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8CY2
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor APNEA (Compound 9) | | 分子名称: | 1,2-ETHANEDIOL, DNA Strand 1, DNA Strand 2, ... | | 著者 | Horton, J.R, Zhou, J, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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8CXY
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor N6-(2-Phenethyl)adenosine (Compound 8) | | 分子名称: | 1,2-ETHANEDIOL, DNA Strand 1, DNA Strand 2, ... | | 著者 | Horton, J.R, Zhou, J, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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8CY5
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 39 | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*TP*TP*CP*AP*AP*AP*AP*AP*GP*TP*CP*CP*CP*A)-3'), N-{3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propyl}adenosine, ... | | 著者 | Zhou, J, Horton, J.R, Cheng, X. | | 登録日 | 2022-05-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J.Med.Chem., 66, 2023
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1CSN
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4GZN
 | | Mouse ZFP57 zinc fingers in complex with methylated DNA | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CALCIUM ION, ... | | 著者 | Liu, Y, Zhang, X, Cheng, X. | | 登録日 | 2012-09-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (0.99 Å) | | 主引用文献 | An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence.
Genes Dev., 26, 2012
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8E3D
 | | ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing CAST sequence (#11) | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*AP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*AP*T)-3'), ... | | 著者 | Horton, J.R, Ren, R, Cheng, X. | | 登録日 | 2022-08-17 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia.
J.Biol.Chem., 299, 2023
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8E3E
 | | ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing CAST sequence (#10) | | 分子名称: | DNA (5'-D(*CP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*A)-3'), ZINC ION, ... | | 著者 | Horton, J.R, Ren, R, Cheng, X. | | 登録日 | 2022-08-17 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia.
J.Biol.Chem., 299, 2023
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8F8Y
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