6MBP
GLP Methyltransferase with Inhibitor EML741- P3121 Crystal Form
Summary for 6MBP
Entry DOI | 10.2210/pdb6mbp/pdb |
Descriptor | Histone-lysine N-methyltransferase EHMT1, 2-cyclohexyl-7-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-8-[3-(pyrrolidin-1-yl)propoxy]-3H-1,4-benzodiazepin-5-amine, ZINC ION, ... (6 entities in total) |
Functional Keywords | histone, h3, methylation inhibition, transferase, transferase-transferase inhbitor complex, transferase/transferase inhbitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 63549.16 |
Authors | Horton, J.R.,Cheng, X. (deposition date: 2018-08-30, release date: 2019-02-27, Last modification date: 2023-10-11) |
Primary citation | Milite, C.,Feoli, A.,Horton, J.R.,Rescigno, D.,Cipriano, A.,Pisapia, V.,Viviano, M.,Pepe, G.,Amendola, G.,Novellino, E.,Cosconati, S.,Cheng, X.,Castellano, S.,Sbardella, G. Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure. J. Med. Chem., 62:2666-2689, 2019 Cited by PubMed: 30753076DOI: 10.1021/acs.jmedchem.8b02008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.947 Å) |
Structure validation
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