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6MBP

GLP Methyltransferase with Inhibitor EML741- P3121 Crystal Form

Functional Information from GO Data
ChainGOidnamespacecontents
A0002039molecular_functionp53 binding
A0005634cellular_componentnucleus
A0008270molecular_functionzinc ion binding
A0016279molecular_functionprotein-lysine N-methyltransferase activity
A0042054molecular_functionhistone methyltransferase activity
B0002039molecular_functionp53 binding
B0005634cellular_componentnucleus
B0008270molecular_functionzinc ion binding
B0016279molecular_functionprotein-lysine N-methyltransferase activity
B0042054molecular_functionhistone methyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue JDG A 2001
ChainResidue
ATYR1124
ATYR1211
AARG1214
APHE1215
ALYS1219
AHOH2109
AHOH2191
AASP1131
AALA1134
AASP1135
AARG1137
AASP1140
ASER1141
ALEU1143
AASP1145

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN A 2002
ChainResidue
ACYS1037
ACYS1074
ACYS1080
ACYS1084

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN A 2003
ChainResidue
ACYS1031
ACYS1044
ACYS1074
ACYS1078

site_idAC4
Number of Residues4
Detailsbinding site for residue ZN A 2004
ChainResidue
ACYS1031
ACYS1033
ACYS1037
ACYS1042

site_idAC5
Number of Residues4
Detailsbinding site for residue ZN A 2005
ChainResidue
ACYS1172
ACYS1225
ACYS1227
ACYS1232

site_idAC6
Number of Residues16
Detailsbinding site for residue SAH A 2006
ChainResidue
AMET1105
ATRP1107
ASER1141
ATYR1142
AARG1166
APHE1167
AASN1169
AHIS1170
ATYR1211
APHE1215
ACYS1225
AARG1226
AHOH2127
AHOH2139
AHOH2222
AHOH2253

site_idAC7
Number of Residues6
Detailsbinding site for residue EDO A 2007
ChainResidue
ACYS1033
AILE1034
AASP1035
ASER1039
AASN1041
BLEU1047

site_idAC8
Number of Residues7
Detailsbinding site for residue EDO A 2008
ChainResidue
AASN1013
ALEU1128
AHIS1185
APHE1190
AARG1192
AHOH2102
AHOH2155

site_idAC9
Number of Residues3
Detailsbinding site for residue EDO A 2009
ChainResidue
AMET1065
APRO1174
AHOH2103

site_idAD1
Number of Residues3
Detailsbinding site for residue EDO A 2010
ChainResidue
AGLY986
AGLU988
AARG989

site_idAD2
Number of Residues3
Detailsbinding site for residue EDO A 2011
ChainResidue
ATYR1161
BALA1077
BHOH1464

site_idAD3
Number of Residues3
Detailsbinding site for residue EDO A 2012
ChainResidue
AALA1077
AHOH2106
AHOH2227

site_idAD4
Number of Residues8
Detailsbinding site for residue EDO A 2013
ChainResidue
AARG985
ATYR987
ALYS1008
ATYR1009
AHOH2236
BCYS1078
BSER1079
BCYS1080

site_idAD5
Number of Residues16
Detailsbinding site for residue JDG B 1301
ChainResidue
BTYR1124
BASP1131
BASP1135
BARG1137
BGLU1138
BASP1140
BSER1141
BLEU1143
BASP1145
BVAL1153
BCYS1155
BTYR1211
BARG1214
BPHE1215
BLYS1219
BEDO1308

site_idAD6
Number of Residues4
Detailsbinding site for residue ZN B 1302
ChainResidue
BCYS1042
BCYS1031
BCYS1033
BCYS1037

site_idAD7
Number of Residues4
Detailsbinding site for residue ZN B 1303
ChainResidue
BCYS1037
BCYS1074
BCYS1080
BCYS1084

site_idAD8
Number of Residues4
Detailsbinding site for residue ZN B 1304
ChainResidue
BCYS1031
BCYS1044
BCYS1074
BCYS1078

site_idAD9
Number of Residues4
Detailsbinding site for residue ZN B 1305
ChainResidue
BCYS1172
BCYS1225
BCYS1227
BCYS1232

site_idAE1
Number of Residues13
Detailsbinding site for residue SAH B 1306
ChainResidue
BMET1105
BTRP1107
BSER1141
BTYR1142
BARG1166
BASN1169
BHIS1170
BTYR1211
BPHE1223
BCYS1225
BARG1226
BHOH1442
BHOH1476

site_idAE2
Number of Residues5
Detailsbinding site for residue EDO B 1307
ChainResidue
BASP1056
BARG1087
BASN1091
BARG1094
BHOH1567

site_idAE3
Number of Residues4
Detailsbinding site for residue EDO B 1308
ChainResidue
BASP1210
BTYR1211
BJDG1301
BHOH1519

site_idAE4
Number of Residues6
Detailsbinding site for residue EDO B 1309
ChainResidue
BASN1075
BHIS1076
BARG1082
BARG1087
BGLN1090
BHOH1518

site_idAE5
Number of Residues4
Detailsbinding site for residue EDO B 1310
ChainResidue
BASP1054
BLYS1055
BARG1085
BHOH1403

site_idAE6
Number of Residues5
Detailsbinding site for residue EDO B 1311
ChainResidue
BCYS1033
BILE1034
BASP1035
BSER1039
BASN1041

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues126
DetailsDomain: {"description":"Pre-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00157","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues234
DetailsDomain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues44
DetailsRegion: {"description":"Interaction with histone H3"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues36
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsSite: {"description":"Histone H3K9me binding","evidences":[{"source":"PubMed","id":"18264113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20084102","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243531

PDB entries from 2025-10-22

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