7JVR

Cryo-EM structure of Bromocriptine-bound dopamine receptor 2 in complex with Gi protein

Summary for 7JVR

• Entry DOI: 10.2210/pdb7jvr/pdb
• EMDB information: 22511
• Descriptor: Soluble cytochrome b562,D(2) dopamine receptor, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: dopamine receptor 2, gi protein, bromocriptine, signaling protein
• Biological source: Escherichia coli; More
• Total number of polymer chains: 5
• Total formula weight: 183124.12

Authors

Zhuang, Y.,Xu, P.,Mao, C.,Wang, L.,Krumm, B.,Zhou, X.E.,Huang, S.,Liu, H.,Cheng, X.,Huang, X.-P.,Sheng, D.-D.,Xu, T.,Liu, Y.-F.,Wang, Y.,Guo, J.,Jiang, Y.,Jiang, H.,Melcher, K.,Roth, B.L.,Zhang, Y.,Zhang, C.,Xu, H.E. (deposition date: 2020-08-22, release date: 2021-02-24, Last modification date: 2021-03-31)

• Primary citation: Zhuang, Y.,Xu, P.,Mao, C.,Wang, L.,Krumm, B.,Zhou, X.E.,Huang, S.,Liu, H.,Cheng, X.,Huang, X.P.,Shen, D.D.,Xu, T.,Liu, Y.F.,Wang, Y.,Guo, J.,Jiang, Y.,Jiang, H.,Melcher, K.,Roth, B.L.,Zhang, Y.,Zhang, C.,Xu, H.E.; Structural insights into the human D1 and D2 dopamine receptor signaling complexes.; Cell, 184:931-942.e18, 2021; PubMed: 33571431; DOI: 10.1016/j.cell.2021.01.027

Experimental method

ELECTRON MICROSCOPY (2.8 Å)