6W4Q
 
 | | Crystal structure of full-length tailspike protein 2 (TSP2, ORF211) ) from Escherichia coli O157:H7 bacteriophage CAB120 | | 分子名称: | 1,2-ETHANEDIOL, CARBONATE ION, CHLORIDE ION, ... | | 著者 | Greenfield, J, Herzberg, O. | | 登録日 | 2020-03-11 | | 公開日 | 2021-01-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure and function of bacteriophage CBA120 ORF211 (TSP2), the determinant of phage specificity towards E. coli O157:H7.
Sci Rep, 10, 2020
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5GN8
 | | Structure of a 48-mer protein nanocage fabricated from its 24-mer analogue by subunit interface redesign | | 分子名称: | CALCIUM ION, Ferritin heavy chain | | 著者 | Zhang, S, Zang, J, Zhao, G, Mikami, B. | | 登録日 | 2016-07-19 | | 公開日 | 2016-12-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.805 Å) | | 主引用文献 | "Silent" Amino Acid Residues at Key Subunit Interfaces Regulate the Geometry of Protein Nanocages
ACS Nano, 10, 2016
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6IZG
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7F6V
 | | Cryo-EM structure of the human TACAN channel in a closed state | | 分子名称: | CHOLESTEROL, Ion channel TACAN | | 著者 | Chen, X.Z, Wang, Y.J, Li, Y, Yang, X, Shen, Y.Q. | | 登録日 | 2021-06-25 | | 公開日 | 2022-02-16 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | | 主引用文献 | Cryo-EM structure of the human TACAN in a closed state.
Cell Rep, 38, 2022
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4Q77
 | | Crystal structure of Rot, a global regulator of virulence genes in Staphylococcus aureus | | 分子名称: | GLYCEROL, HTH-type transcriptional regulator rot | | 著者 | Zhu, Y, Fan, X, Li, X, Teng, M. | | 登録日 | 2014-04-24 | | 公開日 | 2014-09-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Structure of Rot, a global regulator of virulence genes in Staphylococcus aureus.
Acta Crystallogr.,Sect.D, 70, 2014
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7CFS
 | | Cryo-EM strucutre of human acid-sensing ion channel 1a at pH 8.0 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Sun, D.M, Liu, S.L, Li, S.Y, Yang, F, Tian, C.L. | | 登録日 | 2020-06-28 | | 公開日 | 2020-10-21 | | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | | 主引用文献 | Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1.
Elife, 9, 2020
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5GOU
 | | Structure of a 16-mer protein nanocage fabricated from its 24-mer analogue by subunit interface redesign | | 分子名称: | Ferritin heavy chain | | 著者 | Zhang, S, Zang, J, Wang, W, Wang, H, Zhao, G. | | 登録日 | 2016-07-29 | | 公開日 | 2017-02-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Conversion of the Native 24-mer Ferritin Nanocage into Its Non-Native 16-mer Analogue by Insertion of Extra Amino Acid Residues.
Angew. Chem. Int. Ed. Engl., 55, 2016
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6NCL
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7CFT
 | | Cryo-EM strucutre of human acid-sensing ion channel 1a in complex with snake toxin Mambalgin1 at pH 8.0 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, Mambalgin-1 | | 著者 | Sun, D.M, Liu, S.L, Li, S.Y, Yang, F, Tian, C.L. | | 登録日 | 2020-06-28 | | 公開日 | 2020-10-21 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1.
Elife, 9, 2020
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3UI7
 | | Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia | | 分子名称: | 6-methoxy-3,8-dimethyl-4-(morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]quinoline, MAGNESIUM ION, ZINC ION, ... | | 著者 | Yang, S, Smotryski, J, Mcelroy, W, Ho, G, Tulshian, D, Greenlee, W.J, Hodgson, R, Xiao, L, Hruza, A. | | 登録日 | 2011-11-04 | | 公開日 | 2011-12-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
Bioorg.Med.Chem.Lett., 22, 2012
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7T9U
 | | Crystal structure of hSTING with an agonist (SHR169224) | | 分子名称: | (3S,4S)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4-(prop-2-en-1-yl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, CALCIUM ION, Stimulator of interferon genes protein | | 著者 | Chowdhury, R, Miller, M. | | 登録日 | 2021-12-20 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
Sci Rep, 12, 2022
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7T9V
 | | Crystal structure of hSTING with the agonist, SHR171032 | | 分子名称: | (3S,4S)-4-(3-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-benzimidazol-1-yl}propyl)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, CALCIUM ION, Stimulator of interferon genes protein | | 著者 | Chowdhury, R, Miller, M. | | 登録日 | 2021-12-20 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
Sci Rep, 12, 2022
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6O3I
 | | Crystal Structure of Human IDO1 bound to navoximod (NLG-919) | | 分子名称: | Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, trans-4-{(1R)-2-[(5S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl]-1-hydroxyethyl}cyclohexan-1-ol | | 著者 | Harris, S.F, Oh, A. | | 登録日 | 2019-02-26 | | 公開日 | 2019-07-17 | | 最終更新日 | 2019-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Discovery of Clinical Candidate (1R,4r)-4-((R)-2-((S)-6-Fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1.
J.Med.Chem., 62, 2019
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6UKG
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6UKF
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4R28
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8GUE
 | | Crystal Structure of narbomycin-bound cytochrome P450 PikC with the unnatural amino acid p-Acetyl-L-Phenylalanine incorporated at position 238 | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cytochrome P450 monooxygenase PikC, ... | | 著者 | Li, G.B, Pan, Y.J, Li, S.Y, Gao, X. | | 登録日 | 2022-09-11 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Unnatural activities and mechanistic insights of cytochrome P450 PikC gained from site-specific mutagenesis by non-canonical amino acids.
Nat Commun, 14, 2023
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6UKH
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3NFC
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8GU7
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8GT9
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6UKE
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6UKI
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6V62
 | | SETD3 double mutant (N255F/W273A) in Complex with an Actin Peptide with His73 Replaced with Lysine | | 分子名称: | 1,2-ETHANEDIOL, Actin, cytoplasmic 1, ... | | 著者 | Dai, S, Horton, J.R, Cheng, X. | | 登録日 | 2019-12-04 | | 公開日 | 2020-01-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.
J.Biol.Chem., 295, 2020
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6V63
 | | SETD3 WT in Complex with an Actin Peptide with His73 Replaced with Glutamine | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Actin, ... | | 著者 | Dai, S, Horton, J.R, Cheng, X. | | 登録日 | 2019-12-04 | | 公開日 | 2020-01-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.
J.Biol.Chem., 295, 2020
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