2R7B
Crystal Structure of the Phosphoinositide-dependent Kinase-1 (PDK-1)Catalytic Domain bound to a dibenzonaphthyridine inhibitor
Summary for 2R7B
Entry DOI | 10.2210/pdb2r7b/pdb |
Descriptor | 3-phosphoinositide-dependent protein kinase 1, SULFATE ION, 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine, ... (4 entities in total) |
Functional Keywords | pdk1, dibenzonaphthyridine, inhibitor, signaling protein, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: O15530 |
Total number of polymer chains | 1 |
Total formula weight | 36083.29 |
Authors | Olland, A.M. (deposition date: 2007-09-07, release date: 2008-09-09, Last modification date: 2024-03-27) |
Primary citation | Gopalsamy, A.,Shi, M.,Boschelli, D.H.,Williamson, R.,Olland, A.M.,Hu, Y.,Krishnamurthy, G.,Han, X.,Arndt, K.,Guo, B. Discovery of Dibenzo[c,f][2,7]naphthyridines as Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 Inhibitors. J.Med.Chem., 50:5547-5549, 2007 Cited by PubMed: 17941624DOI: 10.1021/jm070851i PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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