4PTC

Structure of a carboxamide compound (3) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-OXO-4H-1LAMBDA~4~,3-THIAZOLE-5-CARBOXAMIDE) to GSK3b

Summary for 4PTC

• Entry DOI: 10.2210/pdb4ptc/pdb
• Related: 4PTE 4PTG
• Descriptor: Glycogen synthase kinase-3 beta, 2-[2-(cyclopropylcarbonylamino)pyridin-4-yl]-4-methoxy-1,3-thiazole-5-carboxamide (3 entities in total)
• Functional Keywords: serine/threonine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 99226.36

Authors

Lewis, H.A.,Sivaprakasam, P.,Kish, K.,Pokross, M.,Dubowchik, G.M. (deposition date: 2014-03-10, release date: 2015-04-08, Last modification date: 2024-02-28)

• Primary citation: Sivaprakasam, P.,Han, X.,Civiello, R.L.,Jacutin-Porte, S.,Kish, K.,Pokross, M.,Lewis, H.A.,Ahmed, N.,Szapiel, N.,Newitt, J.A.,Baldwin, E.T.,Xiao, H.,Krause, C.M.,Park, H.,Nophsker, M.,Lippy, J.S.,Burton, C.R.,Langley, D.R.,Macor, J.E.,Dubowchik, G.M.; Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.; Bioorg.Med.Chem.Lett., 25:1856-1863, 2015; PubMed: 25845281; DOI: 10.1016/j.bmcl.2015.03.046

Experimental method

X-RAY DIFFRACTION (2.711 Å)