8CY4
CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 16
Summary for 8CY4
Entry DOI | 10.2210/pdb8cy4/pdb |
Descriptor | Site-specific DNA-methyltransferase (adenine-specific), DNA (5'-D(*AP*TP*GP*GP*GP*AP*CP*TP*TP*TP*TP*TP*GP*A)-3'), 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | dna adenine methylation, protein-dna complex, transferase, dna binding protein, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Clostridioides difficile More |
Total number of polymer chains | 9 |
Total formula weight | 233897.41 |
Authors | Zhou, J.,Horton, J.R.,Cheng, X. (deposition date: 2022-05-22, release date: 2023-01-11, Last modification date: 2023-10-25) |
Primary citation | Zhou, J.,Horton, J.R.,Menna, M.,Fiorentino, F.,Ren, R.,Yu, D.,Hajian, T.,Vedadi, M.,Mazzoccanti, G.,Ciogli, A.,Weinhold, E.,Huben, M.,Blumenthal, R.M.,Zhang, X.,Mai, A.,Rotili, D.,Cheng, X. Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence. J.Med.Chem., 66:934-950, 2023 Cited by PubMed: 36581322DOI: 10.1021/acs.jmedchem.2c01789 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)