8CY4

CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 16

Summary for 8CY4

• Entry DOI: 10.2210/pdb8cy4/pdb
• Descriptor: Site-specific DNA-methyltransferase (adenine-specific), DNA (5'-D(*AP*TP*GP*GP*GP*AP*CP*TP*TP*TP*TP*TP*GP*A)-3'), 1,2-ETHANEDIOL, ... (7 entities in total)
• Functional Keywords: dna adenine methylation, protein-dna complex, transferase, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Clostridioides difficile; More
• Total number of polymer chains: 9
• Total formula weight: 233897.41

Authors

Zhou, J.,Horton, J.R.,Cheng, X. (deposition date: 2022-05-22, release date: 2023-01-11, Last modification date: 2023-10-25)

• Primary citation: Zhou, J.,Horton, J.R.,Menna, M.,Fiorentino, F.,Ren, R.,Yu, D.,Hajian, T.,Vedadi, M.,Mazzoccanti, G.,Ciogli, A.,Weinhold, E.,Huben, M.,Blumenthal, R.M.,Zhang, X.,Mai, A.,Rotili, D.,Cheng, X.; Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.; J.Med.Chem., 66:934-950, 2023; PubMed: 36581322; DOI: 10.1021/acs.jmedchem.2c01789

Experimental method

X-RAY DIFFRACTION (2.34 Å)