7V6G

Structure of Candida albicans Fructose-1,6-bisphosphate aldolase mutation C157S with CN39

Summary for 7V6G

Entry DOI	10.2210/pdb7v6g/pdb
Descriptor	Fructose-bisphosphate aldolase, ZINC ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	fba, lyase
Biological source	Candida albicans SC5314 (Yeast)
Total number of polymer chains	2
Total formula weight	80989.52
Authors	Cao, H.,Huang, Y.,Chen, H.,Wan, C.,Ren, Y.,Wan, J. (deposition date: 2021-08-20, release date: 2022-02-23, Last modification date: 2023-11-29)
Primary citation	Wen, W.,Cao, H.,Huang, Y.,Tu, J.,Wan, C.,Wan, J.,Han, X.,Chen, H.,Liu, J.,Rao, L.,Su, C.,Peng, C.,Sheng, C.,Ren, Y. Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis. J.Med.Chem., 65:2656-2674, 2022 Cited by DOI: 10.1021/acs.jmedchem.1c02102 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.343 Å)

Structure validation