8TXG

Crystal structure of KRAS G12D in complex with GDP and compound 8

Summary for 8TXG

Entry DOI	10.2210/pdb8txg/pdb
Descriptor	GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	molecule, gtpase, kras, inhibitor, oncoprotein, oncoprotein-inhibitor complex, oncoprotein/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	20470.45
Authors	Chen, P.,Irimia, A.,Yang, Z. (deposition date: 2023-08-23, release date: 2023-11-08)
Primary citation	Cheng, H.,Li, P.,Chen, P.,Irimia, A.,Bae, J.H.,Brooun, A.,Fagan, P.,Lam, R.,Lin, B.,Zhang, J.,Zhan, X.,Wu, X.,Xie, N.,Chiang, G.,Shoemaker, R.,Vernier, J.M. Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors. Acs Med.Chem.Lett., 14:1351-1357, 2023 Cited by PubMed: 37849557 DOI: 10.1021/acsmedchemlett.3c00245 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation