8WQW

Cryo-EM structure of bsAb3 Fab-Gn-Gc complex

Summary for 8WQW

• Entry DOI: 10.2210/pdb8wqw/pdb
• EMDB information: 37756
• Descriptor: Glycoprotein C, bsAb3 Fab-heavy chain, bsAb3 Fab-light chain, ... (6 entities in total)
• Functional Keywords: complex, viral protein, protein binding
• Biological source: Dabie bandavirus (Severe fever with thrombocytopenia syndrome virus); More
• Total number of polymer chains: 6
• Total formula weight: 230486.08

Authors

Wu, Y.,Sun, J.Q. (deposition date: 2023-10-12, release date: 2024-06-12)

• Primary citation: Chang, Z.,Gao, D.,Liao, L.,Sun, J.,Zhang, G.,Zhang, X.,Wang, F.,Li, C.,Oladejo, B.O.,Li, S.,Chai, Y.,Hu, Y.,Lu, X.,Xiao, H.,Qi, J.,Chen, Z.,Gao, F.,Wu, Y.; Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model.; Proc.Natl.Acad.Sci.USA, 121:e2400163121-e2400163121, 2024; PubMed: 38830098; DOI: 10.1073/pnas.2400163121

Experimental method

ELECTRON MICROSCOPY (3.27 Å)