8WQW

Cryo-EM structure of bsAb3 Fab-Gn-Gc complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glycoprotein C	polymer	439	47204.6	1	UniProt (R4V2Q5) Pfam (PF07245) Pfam (PF19019)	Dabie bandavirus (Severe fever with thrombocytopenia syndrome virus)	Gc,Glycoprotein G2
2	B, F (B, F)	bsAb3 Fab-heavy chain	polymer	357	37968.3	2		Homo sapiens
3	C, E (C, E)	bsAb3 Fab-light chain	polymer	333	35276.7	2		Homo sapiens
4	D (D)	Glycoprotein N	polymer	325	35780.5	1	UniProt (R4V2Q5) Pfam (PF07243)	Dabie bandavirus (Severe fever with thrombocytopenia syndrome virus)	Gn,Glycoprotein G1
5	G (G)	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G62182OO)
6	H (H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)

Sequence modifications

A: 563 - 957 (UniProt: R4V2Q5)

PDB	External Database	Details
Val 726	Ala 726	conflict
His 958	-	expression tag
His 959	-	expression tag
His 960	-	expression tag
His 961	-	expression tag
His 962	-	expression tag
His 963	-	expression tag

D: 20 - 344 (UniProt: R4V2Q5)

PDB	External Database	Details
Asp 16	-	expression tag
Gly 17	-	expression tag
Ile 18	-	expression tag
Gln 19	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	229475.1
Branched	Number of molecules	2
	Total formula weight	1010.9
All*	Total formula weight	230486.1

*Water molecules are not included.