7FAU
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![BU of 7fau by Molmil](/molmil-images/mine/7fau) | Structure Determination of the NB1B11-RBD Complex | 分子名称: | NB_1B11, Spike protein S1, ZINC ION | 著者 | Shi, Z.Z, Li, X.X, Wang, L, Sun, Z.C, Zhang, H.W, Chen, X.C, Cui, Q.Q, Qiao, H.R, Lan, Z.Y, Zhang, X. | 登録日 | 2021-07-07 | 公開日 | 2022-06-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Structural basis of nanobodies neutralizing SARS-CoV-2 variants. Structure, 30, 2022
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7WCL
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![BU of 7wcl by Molmil](/molmil-images/mine/7wcl) | Crystal structure of FGFR1 kinase domain with Pemigatinib | 分子名称: | 11-[2,6-bis(fluoranyl)-3,5-dimethoxy-phenyl]-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),2(6),3,7-tetraen-12-one, Fibroblast growth factor receptor 1, SULFATE ION | 著者 | Chen, X.J, Lin, Q.M, Jiang, L.Y, Qu, L.Z, Chen, Y.H. | 登録日 | 2021-12-20 | 公開日 | 2022-09-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.495 Å) | 主引用文献 | Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants. Commun Chem, 5, 2022
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5WHV
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![BU of 5whv by Molmil](/molmil-images/mine/5whv) | Crystal structure of ArtB | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ArtB protein, CALCIUM ION, ... | 著者 | Gao, X, Galan, J.E. | 登録日 | 2017-07-18 | 公開日 | 2017-10-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.303 Å) | 主引用文献 | Evolution of host adaptation in the Salmonella typhoid toxin. Nat Microbiol, 2, 2017
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5WHT
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![BU of 5wht by Molmil](/molmil-images/mine/5wht) | Crystal structure of 3'SL bound PltB | 分子名称: | ACETATE ION, DI(HYDROXYETHYL)ETHER, N-acetyl-alpha-neuraminic acid, ... | 著者 | Gao, X, Galan, J.E. | 登録日 | 2017-07-18 | 公開日 | 2017-10-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.932 Å) | 主引用文献 | Evolution of host adaptation in the Salmonella typhoid toxin. Nat Microbiol, 2, 2017
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7FAT
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![BU of 7fat by Molmil](/molmil-images/mine/7fat) | Structure Determination of the RBD-NB1A7 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, nb_1A7 | 著者 | Geng, Y, Shi, Z.Z, Li, X.Y, Wang, L, Sun, Z.C, Zhang, H.W, Chen, X.C. | 登録日 | 2021-07-07 | 公開日 | 2022-05-18 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural basis of nanobodies neutralizing SARS-CoV-2 variants Structure, 30, 2022
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5WHU
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![BU of 5whu by Molmil](/molmil-images/mine/5whu) | Crystal structure of 3'SL bound ArtB | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ArtB protein, ... | 著者 | Gao, X, Galan, J.E. | 登録日 | 2017-07-18 | 公開日 | 2017-10-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Evolution of host adaptation in the Salmonella typhoid toxin. Nat Microbiol, 2, 2017
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7WZ5
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![BU of 7wz5 by Molmil](/molmil-images/mine/7wz5) | Larimichthys crocea IFNi | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon C | 著者 | Chen, J.J. | 登録日 | 2022-02-17 | 公開日 | 2023-02-08 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Molecular and Structural Basis of Receptor Binding and Signaling of a Fish Type I IFN with Three Disulfide Bonds. J Immunol., 209, 2022
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7F3M
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![BU of 7f3m by Molmil](/molmil-images/mine/7f3m) | Crystal structure of FGFR4 kinase domain with PRN1371 | 分子名称: | 6-[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one, Fibroblast growth factor receptor 4, SULFATE ION | 著者 | Chen, X.J, Qu, L.Z, Dai, S.Y, Wei, H.D, Chen, Y.H. | 登録日 | 2021-06-16 | 公開日 | 2022-01-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.289 Å) | 主引用文献 | Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors Commun Chem, 5, 2022
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7X4X
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![BU of 7x4x by Molmil](/molmil-images/mine/7x4x) | BTB domain of KEAP1 in complex with MEF | 分子名称: | 4-ethoxy-4-oxobutanoic acid, Kelch-like ECH-associated protein 1 | 著者 | Qu, L.Z. | 登録日 | 2022-03-03 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | 主引用文献 | Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates. Biochem.Biophys.Res.Commun., 605, 2022
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7X4W
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7CUN
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![BU of 7cun by Molmil](/molmil-images/mine/7cun) | The structure of human Integrator-PP2A complex | 分子名称: | Integrator complex subunit 1, Integrator complex subunit 11, Integrator complex subunit 2, ... | 著者 | Zheng, H, Qi, Y, Liu, W, Li, J, Wang, J, Xu, Y. | 登録日 | 2020-08-23 | 公開日 | 2020-11-25 | 最終更新日 | 2020-12-09 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase. Science, 370, 2020
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5Y8E
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6ATB
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![BU of 6atb by Molmil](/molmil-images/mine/6atb) | Crystal Structure of human NAMPT in complex with NVP-LOD812 | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-N'-[(pyridin-3-yl)methyl]urea, ... | 著者 | Weihofen, W.A, Thigale, S. | 登録日 | 2017-08-28 | 公開日 | 2018-09-12 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors To Be Published
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6B76
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![BU of 6b76 by Molmil](/molmil-images/mine/6b76) | Crystal Structure of human NAMPT in complex with NVP-LVR596 | 分子名称: | (1S,2S)-N-{4-[(1S)-1-(propanoylamino)ethyl]phenyl}-2-(pyridin-3-yl)cyclopropane-1-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | 著者 | Weihofen, W.A, Thigale, S. | 登録日 | 2017-10-03 | 公開日 | 2018-10-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors To Be Published
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5Y8F
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6AZJ
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![BU of 6azj by Molmil](/molmil-images/mine/6azj) | Crystal Structure of human NAMPT in complex with NVP-LQN520 | 分子名称: | (1S,2S)-N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-(pyridin-3-yl)cyclopropane-1-carboxamide, Nicotinamide phosphoribosyltransferase | 著者 | Weihofen, W.A, Thigale, S. | 登録日 | 2017-09-11 | 公開日 | 2018-09-12 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors To Be Published
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6B75
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![BU of 6b75 by Molmil](/molmil-images/mine/6b75) | Crystal Structure of human NAMPT in complex with NVP-LOQ594 | 分子名称: | 4-[(piperazin-1-yl)methyl]-N-{[4-({[(pyridin-3-yl)methyl]carbamoyl}amino)phenyl]methyl}benzamide, Nicotinamide phosphoribosyltransferase | 著者 | Weihofen, W.A, Thigale, S. | 登録日 | 2017-10-03 | 公開日 | 2018-10-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors To Be Published
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7D2F
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![BU of 7d2f by Molmil](/molmil-images/mine/7d2f) | Lp major histidine acid phosphatase mutant D281A/5'-AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, Major acid phosphatase | 著者 | Guo, Y, Teng, Y. | 登録日 | 2020-09-16 | 公開日 | 2021-09-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural insights into a new substrate binding mode of a histidine acid phosphatase from Legionella pneumophila. Biochem.Biophys.Res.Commun., 540, 2021
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5ZM7
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![BU of 5zm7 by Molmil](/molmil-images/mine/5zm7) | Crystal structure of ORP1-ORD in complex with cholesterol at 3.4 A resolution | 分子名称: | CHOLESTEROL, Oxysterol-binding protein-related protein 1 | 著者 | Dong, J, Wang, J, Wu, J.W. | 登録日 | 2018-04-01 | 公開日 | 2019-02-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.401 Å) | 主引用文献 | Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nat Commun, 10, 2019
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7DOQ
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5ZM6
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![BU of 5zm6 by Molmil](/molmil-images/mine/5zm6) | Crystal structure of ORP1-ORD in complex with PI(4,5)P2 | 分子名称: | ACETATE ION, Oxysterol-binding protein-related protein 1, [(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate | 著者 | Dong, J, Wang, J, Luo, Z, Wu, J.W. | 登録日 | 2018-04-01 | 公開日 | 2019-02-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nat Commun, 10, 2019
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5X4G
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![BU of 5x4g by Molmil](/molmil-images/mine/5x4g) | Crystal structure of Fab fragment of anti-CD147 monoclonal antibody 6H8 | 分子名称: | 6H8 Fab heavy chain, 6H8 Fab light chain | 著者 | Lin, P, Zhang, M.-Y, Chen, X, Ye, S, Yu, X.-L, Zhang, R.-G, Zhu, P, Chen, Z.-N. | 登録日 | 2017-02-13 | 公開日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody To Be Published
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7D57
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![BU of 7d57 by Molmil](/molmil-images/mine/7d57) | C-Src in complex with FIIN-2 | 分子名称: | N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION | 著者 | Chen, Y.H, Qu, L.Z. | 登録日 | 2020-09-25 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.104 Å) | 主引用文献 | Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors Commun Chem, 5, 2022
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6J1Z
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![BU of 6j1z by Molmil](/molmil-images/mine/6j1z) | WWP2 semi-open conformation | 分子名称: | NEDD4-like E3 ubiquitin-protein ligase WWP2 | 著者 | Liu, Z.H. | 登録日 | 2018-12-30 | 公開日 | 2019-07-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases. Nat Commun, 10, 2019
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5X0T
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![BU of 5x0t by Molmil](/molmil-images/mine/5x0t) | Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody 6H8 | 分子名称: | 6H8 Fab fragment heavy chain, 6H8 Fab fragment light chain, Basigin | 著者 | Lin, P, Zhang, M.-Y, Ye, S, Chen, X, Yu, X.-L, Zhang, R.-G, Zhu, P, Chen, Z.-N. | 登録日 | 2017-01-23 | 公開日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody To Be Published
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