4LBM
| Crystal structure of Human galectin-3 CRD in complex with LNT | Descriptor: | CHLORIDE ION, Galectin-3, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | Authors: | Collins, P.M, Blanchard, H. | Deposit date: | 2013-06-20 | Release date: | 2014-01-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Galectin-3 interactions with glycosphingolipids. J.Mol.Biol., 426, 2014
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4LBO
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4CR0
| Crystal Structure of H5 (VN1194) Asn186Lys/Gly143Arg Mutant Haemagglutinin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, Hemagglutinin HA2 | Authors: | Collins, P.J, Vachieri, S.G, Xiong, X, Xiao, H, Martin, S.R, Coombs, P.J, Liu, J, Walker, P.A, Lin, Y.P, McCauley, J.W, Gamblin, S.J, Skehel, J.J. | Deposit date: | 2014-02-21 | Release date: | 2014-05-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Enhanced Human Receptor Binding by H5 Haemagglutinins. Virology, 456, 2014
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3CL0
| N1 Neuraminidase H274Y + oseltamivir | Descriptor: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, Neuraminidase | Authors: | Collins, P, Haire, L.F, Lin, Y.P, Liu, J, Russell, R.J, Walker, P.A, Skehel, J.J, Martin, S.R, Hay, A.J, Gamblin, S.J. | Deposit date: | 2008-03-18 | Release date: | 2008-05-20 | Last modified: | 2018-08-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature, 453, 2008
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3CKZ
| N1 Neuraminidase H274Y + Zanamivir | Descriptor: | CALCIUM ION, Neuraminidase, ZANAMIVIR | Authors: | Colllins, P, Haire, L.F, Lin, Y.P, Liu, J, Russell, R.J, Walker, P.A, Skehel, J.J, Martin, S.R, Hay, A.J, Gamblin, S.J. | Deposit date: | 2008-03-18 | Release date: | 2008-05-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature, 453, 2008
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3CL2
| N1 Neuraminidase N294S + Oseltamivir | Descriptor: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, Neuraminidase | Authors: | Collins, P, Haire, L.F, Lin, Y.P, Liu, J, Russell, R.J, Walker, P.A, Skehel, J.J, Martin, S.R, Hay, A.J, Gamblin, S.J. | Deposit date: | 2008-03-18 | Release date: | 2008-05-20 | Last modified: | 2018-08-22 | Method: | X-RAY DIFFRACTION (2.538 Å) | Cite: | Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature, 453, 2008
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5X0T
| Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody 6H8 | Descriptor: | 6H8 Fab fragment heavy chain, 6H8 Fab fragment light chain, Basigin | Authors: | Lin, P, Zhang, M.-Y, Ye, S, Chen, X, Yu, X.-L, Zhang, R.-G, Zhu, P, Chen, Z.-N. | Deposit date: | 2017-01-23 | Release date: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody To Be Published
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5X4G
| Crystal structure of Fab fragment of anti-CD147 monoclonal antibody 6H8 | Descriptor: | 6H8 Fab heavy chain, 6H8 Fab light chain | Authors: | Lin, P, Zhang, M.-Y, Chen, X, Ye, S, Yu, X.-L, Zhang, R.-G, Zhu, P, Chen, Z.-N. | Deposit date: | 2017-02-13 | Release date: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody To Be Published
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6EW3
| Crystal structure of the metallo-beta-lactamase VIM-2 with ML302F | Descriptor: | (2Z)-2-sulfanyl-3-(2,3,6-trichlorophenyl)prop-2-enoic acid, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Collins, P.M, Brem, J, McDonough, M.A, van Berkel, S.S, von Delft, F, Schofield, C.J. | Deposit date: | 2017-11-03 | Release date: | 2018-10-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases. Bioorg. Med. Chem., 26, 2018
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4DGW
| Crystal Structure of the SF3a splicing factor complex of U2 snRNP | Descriptor: | Pre-mRNA-splicing factor PRP11, Pre-mRNA-splicing factor PRP21, Pre-mRNA-splicing factor PRP9, ... | Authors: | Lin, P.C. | Deposit date: | 2012-01-26 | Release date: | 2012-05-02 | Last modified: | 2018-07-25 | Method: | X-RAY DIFFRACTION (3.112 Å) | Cite: | Structure and assembly of the SF3a splicing factor complex of U2 snRNP Embo J., 31, 2012
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417D
| A THYMINE-LIKE BASE ANALOGUE FORMS WOBBLE PAIRS WITH ADENINE | Descriptor: | DNA (5'-D(*CP*AP*CP*GP*(C46)P*G)-3') | Authors: | Lin, P.K.T, Schuerman, M.H, Moore, G.S, Van Meervelt, L, Loakes, D, Brown, D.M, Moore, M.H. | Deposit date: | 1998-07-15 | Release date: | 1998-09-30 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A thymine-like base analogue forms wobble pairs with adenine in a Z-DNA duplex. J.Mol.Biol., 282, 1998
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5JW3
| Structure of MEDI8852 Fab Fragment in Complex with H7 HA | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Collins, P.J, Neu, U, Walker, P.A, Vorlaender, M.K, Ogrodowicz, R.W, Martin, S.R, Gamblin, S.J, Skehel, J.J. | Deposit date: | 2016-05-11 | Release date: | 2016-08-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.75 Å) | Cite: | Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes. Cell, 166, 2016
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6WZS
| Fusibacterium ulcerans ZTP riboswitch bound to m-1-pyridinyl AICA | Descriptor: | 5-amino-1-(pyridin-3-yl)-1H-imidazole-4-carboxamide, Fusibacterium ulcerans ZTP riboswitch, MAGNESIUM ION, ... | Authors: | Pichling, P, Jones, C.P, Ferre-D'Amare, A.R, Tran, B. | Deposit date: | 2020-05-14 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.23 Å) | Cite: | Parallel Discovery Strategies Provide a Basis for Riboswitch Ligand Design. Cell Chem Biol, 27, 2020
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6WZR
| Fusibacterium ulcerans ZTP riboswitch bound to p-1-pyridinyl AICA | Descriptor: | 5-amino-1-(pyridin-4-yl)-1H-imidazole-4-carboxamide, Fusibacterium ulcerans ZTP riboswitch, MAGNESIUM ION, ... | Authors: | Pichling, P, Jones, C.P, Ferre-D'Amare, A.R, Tran, B. | Deposit date: | 2020-05-14 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Parallel Discovery Strategies Provide a Basis for Riboswitch Ligand Design. Cell Chem Biol, 27, 2020
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4ZI5
| Crystal Structure of Dienelactone Hydrolase-like Promiscuous Phospotriesterase P91 from Metagenomic Libraries | Descriptor: | CHLORIDE ION, MAGNESIUM ION, P91 | Authors: | Colin, P.-Y, Fischer, G, Hyvonen, M, Hollfelder, F. | Deposit date: | 2015-04-27 | Release date: | 2016-02-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.702 Å) | Cite: | Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics. Nat Commun, 6, 2015
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6F83
| Crystal Structure of Human Galectin-1 in Complex With Thienyl-1,2, 3-triazolyl Thiodigalactoside Inhibitor | Descriptor: | 3-deoxy-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-1-thio-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranoside, Galectin-1 | Authors: | Collins, P.M, Blanchard, H. | Deposit date: | 2017-12-12 | Release date: | 2019-01-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands To be published
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7RGY
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7RH0
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7RH1
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7RGZ
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7RH3
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7RH4
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5Y5N
| Crystal structure of human Sirtuin 2 in complex with a selective inhibitor | Descriptor: | 2-[[3-(2-phenylethoxy)phenyl]amino]benzamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION | Authors: | Mellini, P, Itoh, Y, Tsumoto, H, Li, Y, Suzuki, M, Tokuda, N, Kakizawa, T, Miura, Y, Takeuchi, J, Lahtela-Kakkonen, M, Suzuki, T. | Deposit date: | 2017-08-09 | Release date: | 2017-09-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Potent mechanism-based sirtuin-2-selective inhibition by anin situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site. Chem Sci, 8, 2017
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5E89
| Crystal structure of Human galectin-3 CRD in complex with 3-fluophenyl-1,2,3-triazolyl thiodigalactoside inhibitor | Descriptor: | 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside, CHLORIDE ION, Galectin-3 | Authors: | Collins, P.M, Blanchard, H. | Deposit date: | 2015-10-13 | Release date: | 2016-08-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition. Chembiochem, 17, 2016
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5E8A
| Crystal structure of Human galectin-3 CRD in complex with 4-fluophenyl-1,2,3-triazolyl thiodigalactoside inhibitor | Descriptor: | 3-deoxy-3-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside, CHLORIDE ION, Galectin-3 | Authors: | Collins, P.M, Blanchard, H. | Deposit date: | 2015-10-13 | Release date: | 2016-08-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition. Chembiochem, 17, 2016
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