7RGZ

Crystal structure of human galectin-3 CRD in complex with Methyl 2-O-(2-nitro-4-fluoro)-benzoyl-3-O-toluoyl-b-D-talopyranoside

Summary for 7RGZ

Entry DOI	10.2210/pdb7rgz/pdb
Descriptor	Galectin-3, CHLORIDE ION, methyl 2-O-(4-fluoro-2-nitrobenzoyl)-3-O-(4-methylbenzoyl)-beta-D-talopyranoside, ... (4 entities in total)
Functional Keywords	carbohydrates-binding protein, sugar binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	16285.44
Authors	Collins, P.M.,Kishor, C.,Blanchard, H. (deposition date: 2021-07-16, release date: 2022-07-13, Last modification date: 2023-10-18)
Primary citation	Bum-Erdene, K.,Collins, P.M.,Hugo, M.W.,Tarighat, S.S.,Fei, F.,Kishor, C.,Leffler, H.,Nilsson, U.J.,Groffen, J.,Grice, I.D.,Heisterkamp, N.,Blanchard, H. Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia. J.Med.Chem., 65:5975-5989, 2022 Cited by PubMed: 35427125 DOI: 10.1021/acs.jmedchem.1c01296 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.485 Å)

Structure validation