6EW3

Crystal structure of the metallo-beta-lactamase VIM-2 with ML302F

Summary for 6EW3

• Entry DOI: 10.2210/pdb6ew3/pdb
• Related: 4PVO
• Descriptor: Metallo-beta-lactamase VIM-2, ZINC ION, FORMIC ACID, ... (7 entities in total)
• Functional Keywords: metal binding, hydrolase, antibiotic resistance, xchem, complex
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 51024.69

Authors

Collins, P.M.,Brem, J.,McDonough, M.A.,van Berkel, S.S.,von Delft, F.,Schofield, C.J. (deposition date: 2017-11-03, release date: 2018-10-03, Last modification date: 2024-01-17)

• Primary citation: Zhang, D.,Markoulides, M.S.,Stepanovs, D.,Rydzik, A.M.,El-Hussein, A.,Bon, C.,Kamps, J.J.A.G.,Umland, K.D.,Collins, P.M.,Cahill, S.T.,Wang, D.Y.,von Delft, F.,Brem, J.,McDonough, M.A.,Schofield, C.J.; Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases.; Bioorg. Med. Chem., 26:2928-2936, 2018; PubMed: 29655609; DOI: 10.1016/j.bmc.2018.02.043

Experimental method

X-RAY DIFFRACTION (2.14 Å)