6AZJ

Crystal Structure of human NAMPT in complex with NVP-LQN520

Summary for 6AZJ

• Entry DOI: 10.2210/pdb6azj/pdb
• Related: 6atb
• Descriptor: Nicotinamide phosphoribosyltransferase, (1S,2S)-N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-(pyridin-3-yl)cyclopropane-1-carboxamide (3 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 113255.95

Authors

Weihofen, W.A.,Thigale, S. (deposition date: 2017-09-11, release date: 2018-09-12, Last modification date: 2023-10-04)

• Primary citation: Palacios, D.,Meredith, E.,Kawanami, T.,Adams, C.,Chen, X.,Darsigny, V.,Geno, E.,Palermo, M.,Guy, C.,Hewett, J.,Tierney, L.,THigale, S.,Weihofen, W.A.,Agrikar, U.,Boynton, G.,George, E.,Wang, L.; Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.53 Å)