6AZJ
Crystal Structure of human NAMPT in complex with NVP-LQN520
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Nicotinamide phosphoribosyltransferase | polymer | 495 | 56230.6 | 2 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) In PDB | Homo sapiens (Human) | Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin |
2 | A, B | (1S,2S)-N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-(pyridin-3-yl)cyclopropane-1-carboxamide | non-polymer | 397.4 | 2 | Chemie (C5V) | |||
3 | water | water | 18.0 | 291 | Chemie (HOH) |
Sequence modifications
A, B: 8 - 485 (UniProt: P43490)
PDB | External Database | Details |
---|---|---|
Ala -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
Ser -2 | - | expression tag |
Ala -1 | - | expression tag |
Ala 0 | - | expression tag |
Glu 1 | - | expression tag |
Asn 2 | - | expression tag |
Leu 3 | - | expression tag |
Tyr 4 | - | expression tag |
Phe 5 | - | expression tag |
Gln 6 | - | expression tag |
Gly 7 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 112461.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 794.9 | |
All* | Total formula weight | 113256.0 |