6AZJ

Crystal Structure of human NAMPT in complex with NVP-LQN520

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Nicotinamide phosphoribosyltransferase	polymer	495	56230.6	2	UniProt (P43490) Pfam (PF18127) Pfam (PF04095)	Homo sapiens (Human)	Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	C, D (A, B)	(1S,2S)-N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-(pyridin-3-yl)cyclopropane-1-carboxamide	non-polymer		397.4	2	Chemie (C5V)
3	E, F (A, B)	water	water		18.0	291	Chemie (HOH)

Sequence modifications

A, B: 8 - 485 (UniProt: P43490)

PDB	External Database	Details
Ala -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Ser -2	-	expression tag
Ala -1	-	expression tag
Ala 0	-	expression tag
Glu 1	-	expression tag
Asn 2	-	expression tag
Leu 3	-	expression tag
Tyr 4	-	expression tag
Phe 5	-	expression tag
Gln 6	-	expression tag
Gly 7	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	112461.1
Non-Polymers*	Number of molecules	2
	Total formula weight	794.9
All*	Total formula weight	113256.0

*Water molecules are not included.