6ATB
Crystal Structure of human NAMPT in complex with NVP-LOD812
Summary for 6ATB
Entry DOI | 10.2210/pdb6atb/pdb |
Descriptor | Nicotinamide phosphoribosyltransferase, N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-N'-[(pyridin-3-yl)methyl]urea, GLYCEROL, ... (6 entities in total) |
Functional Keywords | complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 230233.60 |
Authors | Weihofen, W.A.,Thigale, S. (deposition date: 2017-08-28, release date: 2018-09-12, Last modification date: 2023-10-04) |
Primary citation | Palacios, D.,Meredith, E.,Kawanami, T.,Adams, C.,Chen, X.,Darsigny, V.,Geno, E.,Palermo, M.,Guy, C.,Hewett, J.,Tierney, L.,THigale, S.,Weihofen, W.A.,Agrikar, U.,Boynton, G.,George, E.,Wang, L. Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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