Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ATB

Crystal Structure of human NAMPT in complex with NVP-LOD812

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006741	biological_process	NADP+ biosynthetic process
A	0006954	biological_process	inflammatory response
A	0007165	biological_process	signal transduction
A	0007267	biological_process	cell-cell signaling
A	0007623	biological_process	circadian rhythm
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008286	biological_process	insulin receptor signaling pathway
A	0009435	biological_process	NAD+ biosynthetic process
A	0010628	biological_process	positive regulation of gene expression
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0032922	biological_process	circadian regulation of gene expression
A	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
A	0042802	molecular_function	identical protein binding
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
A	0048511	biological_process	rhythmic process
A	0060612	biological_process	adipose tissue development
A	0070062	cellular_component	extracellular exosome
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	1901847	biological_process	nicotinate metabolic process
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006741	biological_process	NADP+ biosynthetic process
B	0006954	biological_process	inflammatory response
B	0007165	biological_process	signal transduction
B	0007267	biological_process	cell-cell signaling
B	0007623	biological_process	circadian rhythm
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008286	biological_process	insulin receptor signaling pathway
B	0009435	biological_process	NAD+ biosynthetic process
B	0010628	biological_process	positive regulation of gene expression
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0032922	biological_process	circadian regulation of gene expression
B	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
B	0042802	molecular_function	identical protein binding
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
B	0048511	biological_process	rhythmic process
B	0060612	biological_process	adipose tissue development
B	0070062	cellular_component	extracellular exosome
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	1901847	biological_process	nicotinate metabolic process
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006741	biological_process	NADP+ biosynthetic process
C	0006954	biological_process	inflammatory response
C	0007165	biological_process	signal transduction
C	0007267	biological_process	cell-cell signaling
C	0007623	biological_process	circadian rhythm
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008286	biological_process	insulin receptor signaling pathway
C	0009435	biological_process	NAD+ biosynthetic process
C	0010628	biological_process	positive regulation of gene expression
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0032922	biological_process	circadian regulation of gene expression
C	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
C	0042802	molecular_function	identical protein binding
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
C	0048511	biological_process	rhythmic process
C	0060612	biological_process	adipose tissue development
C	0070062	cellular_component	extracellular exosome
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	1901847	biological_process	nicotinate metabolic process
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0006741	biological_process	NADP+ biosynthetic process
D	0006954	biological_process	inflammatory response
D	0007165	biological_process	signal transduction
D	0007267	biological_process	cell-cell signaling
D	0007623	biological_process	circadian rhythm
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008286	biological_process	insulin receptor signaling pathway
D	0009435	biological_process	NAD+ biosynthetic process
D	0010628	biological_process	positive regulation of gene expression
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0032922	biological_process	circadian regulation of gene expression
D	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
D	0042802	molecular_function	identical protein binding
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
D	0048511	biological_process	rhythmic process
D	0060612	biological_process	adipose tissue development
D	0070062	cellular_component	extracellular exosome
D	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
D	1901847	biological_process	nicotinate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue BWA A 601

Chain	Residue
A	TYR188
A	ARG311
A	ILE351
A	ALA379
A	HOH713
A	HOH774
B	TYR18
A	HIS191
A	PHE193
A	ASP219
A	VAL242
A	ALA244
A	PRO273
A	SER275
A	PRO307

site_id	AC2
Number of Residues	5
Details	binding site for residue GOL A 602

Chain	Residue
A	PHE123
A	VAL124
A	PHE440
A	ASN479
A	HOH715

site_id	AC3
Number of Residues	8
Details	binding site for residue PO4 A 603

Chain	Residue
A	ARG40
A	ARG392
A	SER398
A	LYS400
A	HOH714
A	HOH759
A	HOH785
A	HOH787

site_id	AC4
Number of Residues	17
Details	binding site for residue BWA B 601

Chain	Residue
A	TYR18
B	TYR188
B	HIS191
B	PHE193
B	ARG196
B	ASP219
B	VAL242
B	ALA244
B	SER275
B	PRO307
B	ARG311
B	ARG349
B	ILE351
B	ALA379
B	HOH750
B	HOH786
B	HOH825

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL B 602

Chain	Residue
B	PHE123
B	VAL124
B	ARG434
B	PHE440
B	ASN479
B	HOH728

site_id	AC6
Number of Residues	8
Details	binding site for residue PO4 B 603

Chain	Residue
B	ARG40
B	ARG392
B	SER398
B	LYS400
B	HOH708
B	HOH721
B	HOH739
B	HOH827

site_id	AC7
Number of Residues	2
Details	binding site for residue DMS C 601

Chain	Residue
C	ASP85
C	VAL86

site_id	AC8
Number of Residues	16
Details	binding site for residue BWA C 602

Chain	Residue
C	HIS191
C	PHE193
C	ARG196
C	ASP219
C	VAL242
C	ALA244
C	SER275
C	PRO307
C	ILE309
C	ARG311
C	ILE351
C	ALA379
C	HOH702
C	HOH724
C	HOH816
D	TYR18

site_id	AC9
Number of Residues	5
Details	binding site for residue GOL C 603

Chain	Residue
C	PHE123
C	VAL124
C	ARG434
C	PHE440
C	ASN479

site_id	AD1
Number of Residues	7
Details	binding site for residue GOL C 604

Chain	Residue
C	PHE9
C	ASN10
C	LEU13
D	TYR195
D	GLN201
D	ALA225
D	HOH760

site_id	AD2
Number of Residues	8
Details	binding site for residue PO4 C 605

Chain	Residue
C	ARG40
C	ARG392
C	SER398
C	LYS400
C	HOH703
C	HOH708
C	HOH736
C	HOH751

site_id	AD3
Number of Residues	9
Details	binding site for residue PO4 D 601

Chain	Residue
D	SER398
D	LYS400
D	HOH706
D	HOH708
D	HOH764
D	HOH819
D	HOH839
D	ARG40
D	ARG392

site_id	AD4
Number of Residues	16
Details	binding site for residue BWA D 602

Chain	Residue
C	TYR18
D	HIS191
D	PHE193
D	ASP219
D	VAL242
D	ALA244
D	SER275
D	PRO307
D	ILE309
D	ARG311
D	ARG349
D	ILE351
D	ALA379
D	HOH712
D	HOH779
D	HOH791

site_id	AD5
Number of Residues	5
Details	binding site for residue GOL D 603

Chain	Residue
D	PHE123
D	VAL124
D	ARG434
D	PHE440
D	ASN479

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)