6ATB
Crystal Structure of human NAMPT in complex with NVP-LOD812
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Nicotinamide phosphoribosyltransferase | polymer | 501 | 56942.4 | 4 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) In PDB | Homo sapiens (Human) | Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin |
2 | A, B, C, D | N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-N'-[(pyridin-3-yl)methyl]urea | non-polymer | 386.4 | 4 | Chemie (BWA) | |||
3 | A, B, C, D | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
4 | A, B, C, D | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
5 | C | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
6 | water | water | 18.0 | 1123 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 491 (UniProt: P43490)
PDB | External Database | Details |
---|---|---|
Leu 492 | - | expression tag |
Glu 493 | - | expression tag |
His 494 | - | expression tag |
His 495 | - | expression tag |
His 496 | - | expression tag |
His 497 | - | expression tag |
His 498 | - | expression tag |
His 499 | - | expression tag |
His 500 | - | expression tag |
His 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 227769.5 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 2464.1 | |
All* | Total formula weight | 230233.6 |