5ZM6

Crystal structure of ORP1-ORD in complex with PI(4,5)P2

Summary for 5ZM6

• Entry DOI: 10.2210/pdb5zm6/pdb
• Descriptor: Oxysterol-binding protein-related protein 1, [(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate, ACETATE ION, ... (4 entities in total)
• Functional Keywords: transporter, complex, phospholipid, lipid transport
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 103268.90

Authors

Dong, J.,Wang, J.,Luo, Z.,Wu, J.W. (deposition date: 2018-04-01, release date: 2019-02-27, Last modification date: 2023-11-22)

• Primary citation: Dong, J.,Du, X.,Wang, H.,Wang, J.,Lu, C.,Chen, X.,Zhu, Z.,Luo, Z.,Yu, L.,Brown, A.J.,Yang, H.,Wu, J.W.; Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.; Nat Commun, 10:829-829, 2019; PubMed: 30783101; DOI: 10.1038/s41467-019-08791-0

Experimental method

X-RAY DIFFRACTION (2.7 Å)