7F3M

Crystal structure of FGFR4 kinase domain with PRN1371

Summary for 7F3M

• Entry DOI: 10.2210/pdb7f3m/pdb
• Descriptor: Fibroblast growth factor receptor 4, 6-[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, complex, structural protein, transferase-transferase inhibitor complex, transferase-transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35544.71

Authors

Chen, X.J.,Qu, L.Z.,Dai, S.Y.,Wei, H.D.,Chen, Y.H. (deposition date: 2021-06-16, release date: 2022-01-12, Last modification date: 2023-11-29)

• Primary citation: Qu, L.,Chen, X.,Wei, H.,Guo, M.,Dai, S.,Jiang, L.,Li, J.,Yue, S.,Chen, Z.,Chen, Y.; Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors; Commun Chem, 5:5-, 2022; DOI: 10.1038/s42004-021-00623-x

Experimental method

X-RAY DIFFRACTION (2.289 Å)