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6B76

Crystal Structure of human NAMPT in complex with NVP-LVR596

Summary for 6B76
Entry DOI10.2210/pdb6b76/pdb
Related6B75 6atb 6azj
DescriptorNicotinamide phosphoribosyltransferase, (1S,2S)-N-{4-[(1S)-1-(propanoylamino)ethyl]phenyl}-2-(pyridin-3-yl)cyclopropane-1-carboxamide, PHOSPHATE ION, ... (4 entities in total)
Functional Keywordstransferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight230163.85
Authors
Weihofen, W.A.,Thigale, S. (deposition date: 2017-10-03, release date: 2018-10-03, Last modification date: 2023-10-04)
Primary citationPalacios, D.,Meredith, E.,Kawanami, T.,Adams, C.,Chen, X.,Darsigny, V.,Geno, E.,Palermo, M.,Guy, C.,Hewett, J.,Tierney, L.,THigale, S.,Weihofen, W.A.,Agrikar, U.,Boynton, G.,George, E.,Wang, L.
Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.44 Å)
Structure validation

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