Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6B76

Crystal Structure of human NAMPT in complex with NVP-LVR596

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006741	biological_process	NADP+ biosynthetic process
A	0006954	biological_process	inflammatory response
A	0007165	biological_process	signal transduction
A	0007267	biological_process	cell-cell signaling
A	0007623	biological_process	circadian rhythm
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008286	biological_process	insulin receptor signaling pathway
A	0009435	biological_process	NAD+ biosynthetic process
A	0010628	biological_process	positive regulation of gene expression
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0032922	biological_process	circadian regulation of gene expression
A	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
A	0042802	molecular_function	identical protein binding
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
A	0048511	biological_process	rhythmic process
A	0060612	biological_process	adipose tissue development
A	0070062	cellular_component	extracellular exosome
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	1901847	biological_process	nicotinate metabolic process
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006741	biological_process	NADP+ biosynthetic process
B	0006954	biological_process	inflammatory response
B	0007165	biological_process	signal transduction
B	0007267	biological_process	cell-cell signaling
B	0007623	biological_process	circadian rhythm
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008286	biological_process	insulin receptor signaling pathway
B	0009435	biological_process	NAD+ biosynthetic process
B	0010628	biological_process	positive regulation of gene expression
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0032922	biological_process	circadian regulation of gene expression
B	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
B	0042802	molecular_function	identical protein binding
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
B	0048511	biological_process	rhythmic process
B	0060612	biological_process	adipose tissue development
B	0070062	cellular_component	extracellular exosome
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	1901847	biological_process	nicotinate metabolic process
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006741	biological_process	NADP+ biosynthetic process
C	0006954	biological_process	inflammatory response
C	0007165	biological_process	signal transduction
C	0007267	biological_process	cell-cell signaling
C	0007623	biological_process	circadian rhythm
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008286	biological_process	insulin receptor signaling pathway
C	0009435	biological_process	NAD+ biosynthetic process
C	0010628	biological_process	positive regulation of gene expression
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0032922	biological_process	circadian regulation of gene expression
C	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
C	0042802	molecular_function	identical protein binding
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
C	0048511	biological_process	rhythmic process
C	0060612	biological_process	adipose tissue development
C	0070062	cellular_component	extracellular exosome
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	1901847	biological_process	nicotinate metabolic process
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0006741	biological_process	NADP+ biosynthetic process
D	0006954	biological_process	inflammatory response
D	0007165	biological_process	signal transduction
D	0007267	biological_process	cell-cell signaling
D	0007623	biological_process	circadian rhythm
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008286	biological_process	insulin receptor signaling pathway
D	0009435	biological_process	NAD+ biosynthetic process
D	0010628	biological_process	positive regulation of gene expression
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0032922	biological_process	circadian regulation of gene expression
D	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
D	0042802	molecular_function	identical protein binding
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
D	0048511	biological_process	rhythmic process
D	0060612	biological_process	adipose tissue development
D	0070062	cellular_component	extracellular exosome
D	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
D	1901847	biological_process	nicotinate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue CVJ A 601

Chain	Residue
A	TYR188
A	ILE351
A	ALA379
A	HOH919
A	HOH945
B	ASP16
B	TYR18
A	HIS191
A	PHE193
A	ARG196
A	ASP219
A	VAL242
A	ALA244
A	SER275
A	ARG311

site_id	AC2
Number of Residues	9
Details	binding site for residue PO4 A 602

Chain	Residue
A	ARG40
A	ARG392
A	CYS397
A	SER398
A	LYS400
A	HOH804
A	HOH820
A	HOH899
B	HOH713

site_id	AC3
Number of Residues	11
Details	binding site for residue PO4 A 603

Chain	Residue
A	ARG196
A	ALA245
A	GLU246
A	HIS247
A	ARG311
A	ASP313
A	HOH836
A	HOH968
A	HOH994
B	TYR18
B	HOH746

site_id	AC4
Number of Residues	8
Details	binding site for residue PO4 A 604

Chain	Residue
A	GLY355
A	GLY383
A	GLY384
A	HOH857
A	HOH865
A	HOH869
A	HOH964
B	ARG392

site_id	AC5
Number of Residues	15
Details	binding site for residue CVJ B 601

Chain	Residue
A	TYR18
B	TYR188
B	HIS191
B	PHE193
B	ARG196
B	ASP219
B	VAL242
B	ALA244
B	SER275
B	ARG311
B	ALA379
B	HOH753
B	HOH776
B	HOH777
B	HOH820

site_id	AC6
Number of Residues	8
Details	binding site for residue PO4 B 602

Chain	Residue
A	TYR18
B	ARG196
B	GLU246
B	HIS247
B	ARG311
B	ASP313
B	HOH711
B	HOH719

site_id	AC7
Number of Residues	8
Details	binding site for residue PO4 B 603

Chain	Residue
A	ARG392
A	HOH855
B	GLY383
B	GLY384
B	HOH701
B	HOH728
B	HOH810
B	HOH843

site_id	AC8
Number of Residues	9
Details	binding site for residue PO4 B 604

Chain	Residue
B	ARG40
B	ARG392
B	SER398
B	LYS400
B	LYS423
B	HOH733
B	HOH738
B	HOH746
B	HOH784

site_id	AC9
Number of Residues	15
Details	binding site for residue CVJ C 601

Chain	Residue
C	TYR188
C	HIS191
C	PHE193
C	ARG196
C	ASP219
C	VAL242
C	ALA244
C	SER275
C	ARG311
C	ILE351
C	ALA379
C	HOH749
C	HOH780
C	HOH782
D	TYR18

site_id	AD1
Number of Residues	7
Details	binding site for residue PO4 C 602

Chain	Residue
C	HIS247
C	ARG311
C	HOH810
D	TYR18
D	HOH715
D	HOH754
C	GLU246

site_id	AD2
Number of Residues	6
Details	binding site for residue PO4 C 603

Chain	Residue
C	GLY353
C	GLY383
C	GLY384
C	HOH706
C	HOH773
D	ARG392

site_id	AD3
Number of Residues	3
Details	binding site for residue PO4 C 604

Chain	Residue
C	ARG40
C	ARG392
C	SER398

site_id	AD4
Number of Residues	13
Details	binding site for residue CVJ D 601

Chain	Residue
C	ASP16
C	TYR18
D	TYR188
D	HIS191
D	PHE193
D	ARG196
D	ASP219
D	VAL242
D	ALA244
D	SER275
D	ARG311
D	ILE351
D	ALA379

site_id	AD5
Number of Residues	7
Details	binding site for residue PO4 D 602

Chain	Residue
D	ARG40
D	ARG392
D	SER398
D	LYS400
D	HOH706
D	HOH718
D	HOH750

site_id	AD6
Number of Residues	6
Details	binding site for residue PO4 D 603

Chain	Residue
C	ARG392
D	GLY353
D	GLY383
D	GLY384
D	GLY385
D	HOH814

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)