3SPG
 
 | | Inward rectifier potassium channel Kir2.2 R186A mutant in complex with PIP2 | | 分子名称: | Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | 著者 | Hansen, S.B, Tao, X, MacKinnon, R. | | 登録日 | 2011-07-01 | | 公開日 | 2011-08-24 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.613 Å) | | 主引用文献 | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2.
Nature, 477, 2011
|
|
8ED7
 | | cryo-EM structure of TRPM3 ion channel in apo state | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, Transient receptor potential cation channel, subfamily M, ... | | 著者 | Zhao, C, MacKinnon, R. | | 登録日 | 2022-09-03 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
|
|
8ED8
 | | cryo-EM structure of TRPM3 ion channel in the presence of PIP2 and PregS, state 1 | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ... | | 著者 | Zhao, C, MacKinnon, R. | | 登録日 | 2022-09-03 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
|
|
3SPI
 | | Inward rectifier potassium channel Kir2.2 in complex with PIP2 | | 分子名称: | Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | 著者 | Hansen, S.B, Tao, X, MacKinnon, R. | | 登録日 | 2011-07-01 | | 公開日 | 2011-08-24 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.307 Å) | | 主引用文献 | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2.
Nature, 477, 2011
|
|
8ED9
 | | cryo-EM structure of TRPM3 ion channel in the presence with PIP2 and PregS, state 2 | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ... | | 著者 | Zhao, C, MacKinnon, R. | | 登録日 | 2022-09-03 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
|
|
3SYQ
 | | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) R201A mutant in complex with PIP2 | | 分子名称: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | 著者 | Whorton, M.R, MacKinnon, R. | | 登録日 | 2011-07-18 | | 公開日 | 2011-10-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.44 Å) | | 主引用文献 | Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium.
Cell(Cambridge,Mass.), 147, 2011
|
|
3SPJ
 | |
8EMV
 | | Phospholipase C beta 3 (PLCb3) in solution | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION | | 著者 | Falzone, M.E, MacKinnon, R. | | 登録日 | 2022-09-28 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8EMW
 | | Phospholipase C beta 3 (PLCb3) in complex with Gbg on liposomes | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Falzone, M.E, MacKinnon, R. | | 登録日 | 2022-09-28 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8EMX
 | |
3SYA
 | | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with sodium and PIP2 | | 分子名称: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, SODIUM ION, ... | | 著者 | Whorton, M.R, MacKinnon, R. | | 登録日 | 2011-07-16 | | 公開日 | 2011-10-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium.
Cell(Cambridge,Mass.), 147, 2011
|
|
3SPH
 | | Inward rectifier potassium channel Kir2.2 I223L mutant in complex with PIP2 | | 分子名称: | Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | 著者 | Hansen, S.B, Tao, X, MacKinnon, R. | | 登録日 | 2011-07-01 | | 公開日 | 2011-08-24 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.003 Å) | | 主引用文献 | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2.
Nature, 477, 2011
|
|
3UM7
 | |
3EB4
 | | Voltage-dependent K+ channel beta subunit (I211R) in complex with cortisone | | 分子名称: | 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Voltage-gated potassium channel subunit beta-2 | | 著者 | Pan, Y, Weng, J, Kabaleeswaran, V, Li, H, Cao, Y, Bhosle, R.C, Zhou, M. | | 登録日 | 2008-08-26 | | 公開日 | 2008-09-23 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Cortisone dissociates the Shaker family K+ channels from their beta subunits.
Nat.Chem.Biol., 4, 2008
|
|
3LUT
 | | A Structural Model for the Full-length Shaker Potassium Channel Kv1.2 | | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 2, ... | | 著者 | Chen, X, Ni, F, Wang, Q, Ma, J. | | 登録日 | 2010-02-18 | | 公開日 | 2010-06-23 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement.
Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
3EB3
 | | Voltage-dependent K+ channel beta subunit (W121A) in complex with cortisone | | 分子名称: | 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Voltage-gated potassium channel subunit beta-2 | | 著者 | Pan, Y, Weng, J, Kabaleeswaran, V, Li, H, Cao, Y, Bhosle, R.C, Zhou, M. | | 登録日 | 2008-08-26 | | 公開日 | 2008-09-23 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Cortisone dissociates the Shaker family K+ channels from their beta subunits.
Nat.Chem.Biol., 4, 2008
|
|
3EAU
 | | Voltage-dependent K+ channel beta subunit in complex with cortisone | | 分子名称: | 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Voltage-gated potassium channel subunit beta-2 | | 著者 | Pan, Y, Weng, J, Kabaleeswaran, V, Li, H, Cao, Y, Bhosle, R.C, Zhou, M. | | 登録日 | 2008-08-26 | | 公開日 | 2008-09-23 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Cortisone dissociates the Shaker family K+ channels from their beta subunits.
Nat.Chem.Biol., 4, 2008
|
|
6PIS
 | |
1JQ1
 | |
3JYC
 | |
2AEM
 | | Crystal Structures of the MthK RCK Domain | | 分子名称: | Calcium-gated potassium channel mthK | | 著者 | Dong, J, Shi, N, Berke, I, Chen, L, Jiang, Y. | | 登録日 | 2005-07-22 | | 公開日 | 2005-10-25 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structures of the MthK RCK Domain and the Effect of Ca2+ on Gating Ring Stability
J.Biol.Chem., 280, 2005
|
|
2AEJ
 | | Crystal Structures of the MthK RCK Domain in no Ca2+ bound form | | 分子名称: | Calcium-gated potassium channel mthK | | 著者 | Dong, J, Shi, N, Berke, I, Chen, L, Jiang, Y. | | 登録日 | 2005-07-22 | | 公開日 | 2005-10-25 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structures of the MthK RCK Domain and the Effect of Ca2+ on Gating Ring Stability
J.Biol.Chem., 280, 2005
|
|
1G9O
 | | FIRST PDZ DOMAIN OF THE HUMAN NA+/H+ EXCHANGER REGULATORY FACTOR | | 分子名称: | NHE-RF | | 著者 | Karthikeyan, S, Leung, T, Birrane, G, Webster, G, Ladias, J.A.A. | | 登録日 | 2000-11-26 | | 公開日 | 2001-05-23 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains.
J.Mol.Biol., 308, 2001
|
|
1JQ2
 | |
2FED
 | | Structure of the E203Q mutant of the Cl-/H+ exchanger CLC-ec1 from E.Coli | | 分子名称: | Fab fragment, heavy chain, light chain, ... | | 著者 | Accardi, A, Walden, M.P, Nguitragool, W, Jayaram, H, Williams, C, Miller, C. | | 登録日 | 2005-12-15 | | 公開日 | 2006-01-03 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.317 Å) | | 主引用文献 | Separate ion pathways in a Cl-/H+ exchanger
J.Gen.Physiol., 126, 2005
|
|
