8EMX

Phospholipase C beta 3 (PLCb3) in complex with Gbg on lipid nanodiscs

Summary for 8EMX

• Entry DOI: 10.2210/pdb8emx/pdb
• Related: 8EMV 8EMW
• EMDB information: 28266 28267 28268
• Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (4 entities in total)
• Functional Keywords: pip2 degradation, ip3 production, dag production, g protein signaling, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 229365.40

Authors

Falzone, M.E.,MacKinnon, R. (deposition date: 2022-09-28, release date: 2023-05-24)

• Primary citation: Falzone, M.E.,MacKinnon, R.; G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.; Proc.Natl.Acad.Sci.USA, 120:e2301121120-e2301121120, 2023; PubMed: 37172014; DOI: 10.1073/pnas.2301121120

Experimental method

ELECTRON MICROSCOPY (3.3 Å)