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3SYQ

Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) R201A mutant in complex with PIP2

Summary for 3SYQ
Entry DOI10.2210/pdb3syq/pdb
Related3SYA 3SYC 3SYO 3SYP
DescriptorG protein-activated inward rectifier potassium channel 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, POTASSIUM ION (3 entities in total)
Functional Keywordsion channel, potassium channel, inward rectification, sodium binding, pip2 binding, g protein binding, metal transport
Biological sourceMus musculus (mouse)
Cellular locationMembrane; Multi-pass membrane protein: P48542
Total number of polymer chains2
Total formula weight78854.65
Authors
Whorton, M.R.,MacKinnon, R. (deposition date: 2011-07-18, release date: 2011-10-12, Last modification date: 2023-09-13)
Primary citationWhorton, M.R.,Mackinnon, R.
Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium.
Cell(Cambridge,Mass.), 147:199-208, 2011
Cited by
PubMed: 21962516
DOI: 10.1016/j.cell.2011.07.046
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.44 Å)
Structure validation

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