3SYQ
Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) R201A mutant in complex with PIP2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | G protein-activated inward rectifier potassium channel 2 | polymer | 340 | 38975.8 | 2 | UniProt (P48542) Pfam (PF01007) Pfam (PF17655) | Mus musculus (mouse) | GIRK-2, Inward rectifier K(+) channel Kir3.2, Potassium channel, inwardly rectifying subfamily J member 6 |
| 2 | C (A) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 1 | Chemie (PIO) | |||
| 3 | D, E, F, G (A) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) |
Sequence modifications
A, B: 52 - 380 (UniProt: P48542)
| PDB | External Database | Details |
|---|---|---|
| Met 50 | - | expression tag |
| Ala 51 | - | expression tag |
| Ala 201 | Arg 201 | engineered mutation |
| Thr 260 | Ser 260 | SEE REMARK 999 |
| Met 313 | Ile 313 | SEE REMARK 999 |
| Leu 344 | Met 344 | SEE REMARK 999 |
| Ser 381 | - | expression tag |
| Asn 382 | - | expression tag |
| Ser 383 | - | expression tag |
| Leu 384 | - | expression tag |
| Glu 385 | - | expression tag |
| Val 386 | - | expression tag |
| Leu 387 | - | expression tag |
| Phe 388 | - | expression tag |
| Gln 389 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77951.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 903.0 | |
| All* | Total formula weight | 78854.6 |
