8EMV

Phospholipase C beta 3 (PLCb3) in solution

Summary for 8EMV

Entry DOI	10.2210/pdb8emv/pdb
Related	8EMW 8EMX
EMDB information	28266 28267 28268
Descriptor	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION (2 entities in total)
Functional Keywords	pip2 degradation, ip3 production, dag production, g protein signaling, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	138870.50
Authors	Falzone, M.E.,MacKinnon, R. (deposition date: 2022-09-28, release date: 2023-05-24)
Primary citation	Falzone, M.E.,MacKinnon, R. G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface. Proc.Natl.Acad.Sci.USA, 120:e2301121120-e2301121120, 2023 Cited by PubMed: 37172014 DOI: 10.1073/pnas.2301121120 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation