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3N8V
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Crystal Structure of Unoccupied Cyclooxygenase-1
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
著者Sidhu, R.S.
登録日2010-05-28
公開日2010-07-28
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers
Biochemistry, 49, 2010
3N8W
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Crystal Structure of R120Q/Native Cyclooxygenase-1 Heterodimer mutant in complex with Flurbiprofen
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FLURBIPROFEN, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Sidhu, R.S.
登録日2010-05-28
公開日2010-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers
Biochemistry, 49, 2010
3N8Y
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Structure of Aspirin Acetylated Cyclooxygenase-1 in Complex with Diclofenac
分子名称: 2-HYDROXYBENZOIC ACID, 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Sidhu, R.S.
登録日2010-05-28
公開日2010-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers
Biochemistry, 49, 2010
3N8Z
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Crystal Structure of Cyclooxygenase-1 in Complex with Flurbiprofen
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FLURBIPROFEN, ...
著者Sidhu, R.S.
登録日2010-05-28
公開日2010-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers
Biochemistry, 49, 2010
5TAB
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BU of 5tab by Molmil
Crystal Structure of the PHD Finger of PHF20
分子名称: GLYCEROL, PHD finger protein 20, ZINC ION
著者Klein, B.J, Kutateladze, T.G.
登録日2016-09-09
公開日2016-10-26
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
Cell Rep, 17, 2016
3N8X
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Crystal Structure of Cyclooxygenase-1 in Complex with Nimesulide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-NITRO-2-PHENOXYMETHANESULFONANILIDE, ...
著者Lee, J.Y.
登録日2010-05-28
公開日2010-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers
Biochemistry, 49, 2010
2N3K
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Human Brd4 ET domain in complex with MLV Integrase C-term
分子名称: Bromodomain-containing protein 4, MLV integrase
著者Crowe, B.L, Foster, M.P.
登録日2015-06-03
公開日2016-03-02
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structure of the Brd4 ET domain bound to a C-terminal motif from gamma-retroviral integrases reveals a conserved mechanism of interaction.
Proc.Natl.Acad.Sci.USA, 113, 2016
5YQN
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Crystal structure of Sirt2 in complex with selective inhibitor L55
分子名称: DI(HYDROXYETHYL)ETHER, N-[3-[[3-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanoylamino]phenyl]methoxy]phenyl]-1-methyl-pyrazole-4-carboxamide, NAD-dependent protein deacetylase sirtuin-2, ...
著者Wang, H, Yu, Y, Li, G, Chen, Q.
登録日2017-11-07
公開日2018-10-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Eur J Med Chem, 155, 2018
5YQO
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Crystal structure of Sirt2 in complex with selective inhibitor L5C
分子名称: N-[4-[[3-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanoylamino]phenyl]methoxy]phenyl]-1-methyl-pyrazole-4-carboxamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION
著者Wang, H, Yu, Y, Li, G, Chen, Q.
登録日2017-11-07
公開日2018-10-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.483 Å)
主引用文献X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Eur J Med Chem, 155, 2018
5YQL
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Crystal structure of Sirt2 in complex with selective inhibitor A2I
分子名称: 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[3-(phenoxymethyl)phenyl]ethanamide, BETA-MERCAPTOETHANOL, NAD-dependent protein deacetylase sirtuin-2, ...
著者Wang, H, Yu, Y, Li, G, Chen, Q.
登録日2017-11-07
公開日2018-10-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Eur J Med Chem, 155, 2018
5YQM
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Crystal structure of Sirt2 in complex with selective inhibitor A29
分子名称: 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-(4-phenylsulfanylphenyl)ethanamide, BETA-MERCAPTOETHANOL, NAD-dependent protein deacetylase sirtuin-2, ...
著者Wang, H, Yu, Y, Li, G, chen, Q.
登録日2017-11-07
公開日2018-10-17
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.735 Å)
主引用文献X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Eur J Med Chem, 155, 2018
7FB8
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De Novo-Designed and Disulfide-Bridged Peptide Heterodimer - hd1
分子名称: ASP-ASP-LYS-ASP-CYS-ASP-GLU-TYR-CYS-LYS-LYS-THR-LYS-GLU-NH2, GLU-LE1-THR-GLY-HIS-ILE-GLU-GLY-PRO-THR-LE1-THR-LE1-HIS-CYS-LYS-NH2
著者Yao, H, Yao, S, Zheng, Y, Moyer, A, Baker, D, Wu, C.
登録日2021-07-08
公開日2022-05-18
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献De novo design and directed folding of disulfide-bridged peptide heterodimers.
Nat Commun, 13, 2022
7FBA
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De Novo-Designed and Disulfide-Bridged Peptide Heterodimer - hd2
分子名称: ALA-LE1-CYS-GLU-CYS-GLY-PRO-THR-ARG-GLU-CYS-LYS-NH2, GLU-CYS-ARG-GLU-TYR-GLY-PRO-LE1-LYS-LE1-LE1-ALA-NH2
著者Yao, H, Yao, S, Moyer, A, Zheng, Y, Baker, D, Wu, C.
登録日2021-07-08
公開日2022-05-18
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献De novo design and directed folding of disulfide-bridged peptide heterodimers.
Nat Commun, 13, 2022
4K24
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Structure of anti-uPAR Fab ATN-658 in complex with uPAR
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, ...
著者Huang, M.D, Xu, X, Yuan, C.
登録日2013-04-08
公開日2014-02-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (4.5 Å)
主引用文献Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b ( alpha M)
Plos One, 9, 2014
5YC7
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The crystal structure of uPA in complex with 4-Bromobenzylamirne at pH7.4
分子名称: 1-(4-BROMOPHENYL)METHANAMINE, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L.G, Zhang, X, Huang, M.D.
登録日2017-09-06
公開日2018-10-03
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases
Rsc Adv, 8, 2018
6A2F
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Crystal structure of biosynthetic alanine racemase from Pseudomonas aeruginosa
分子名称: ACETATE ION, Alanine racemase, biosynthetic, ...
著者Dong, H, Li, S.
登録日2018-06-11
公開日2018-08-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Enzymatic characterization and crystal structure of biosynthetic alanine racemase from Pseudomonas aeruginosa PAO1.
Biochem.Biophys.Res.Commun., 503, 2018
5XG4
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Crystal structure of uPA in complex with quercetin
分子名称: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, Urokinase-type plasminogen activator
著者Jiang, L, Huang, M.
登録日2017-04-11
公開日2017-07-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A structural mechanism of flavonoids in inhibiting serine proteases
Food Funct, 8, 2017
5Z1C
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The crystal structure of uPA in complex with 4-Iodobenzylamine at pH7.4
分子名称: 1-(4-iodophenyl)methanamine, Urokinase-type plasminogen activator
著者Jiang, L.G, Zhang, X, Luo, Z.P, Huang, M.D.
登録日2017-12-25
公開日2018-12-26
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases
Rsc Adv, 49, 2018
7WN7
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Crystal structure of HearNPV P26
分子名称: CHLORIDE ION, SULFATE ION, p26
著者Kuang, W, Hu, Z, Gong, P.
登録日2022-01-17
公開日2022-11-23
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity.
Nat Commun, 13, 2022
6AEX
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Crystal structure of unoccupied murine uPAR
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor
著者Min, L, Huang, M.
登録日2018-08-06
公開日2019-07-17
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.393 Å)
主引用文献Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit.
Febs Lett., 593, 2019
5YC6
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The crystal structure of uPA in complex with 4-Bromobenzylamirne at pH4.6
分子名称: 1-(4-BROMOPHENYL)METHANAMINE, SULFATE ION, TRIETHYLENE GLYCOL, ...
著者Jiang, L.G, Zhang, X, Huang, M.D.
登録日2017-09-06
公開日2018-10-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.18 Å)
主引用文献Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases
Rsc Adv, 8, 2018
7E17
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Structure of dimeric uPAR
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor
著者Cai, Y, Huang, M.
登録日2021-02-01
公開日2021-12-22
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Crystal structure and cellular functions of uPAR dimer
Nat Commun, 13, 2022
7YOV
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Cryo-EM structure of RNA polymerase in complex with P protein tetramer of Newcastle disease virus
分子名称: NDV P protein, RNA-directed RNA polymerase L
著者Chen, Y, Jingyuan, C, Xiaoying, F.
登録日2022-08-02
公開日2023-02-15
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Structure of the Newcastle Disease Virus L protein in complex with tetrameric phosphoprotein.
Nat Commun, 14, 2023
7YOT
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Cryo-EM structure of RNA polymerase in complex with P protein tetramer of Newcastle disease virus
分子名称: NDV P protein, RNA-directed RNA polymerase L
著者Chen, Y, Jingyuan, C.
登録日2022-08-02
公開日2023-02-15
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structure of the Newcastle Disease Virus L protein in complex with tetrameric phosphoprotein.
Nat Commun, 14, 2023
7YOU
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Cryo-EM structure of RNA polymerase in complex with P protein tetramer of Newcastle disease virus
分子名称: NDV P protein, RNA-directed RNA polymerase L
著者Chen, Y, Jingyuan, C, Xiaoying, F.
登録日2022-08-02
公開日2023-02-15
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献Structure of the Newcastle Disease Virus L protein in complex with tetrameric phosphoprotein.
Nat Commun, 14, 2023

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