3N8X

Crystal Structure of Cyclooxygenase-1 in Complex with Nimesulide

Summary for 3N8X

Entry DOI	10.2210/pdb3n8x/pdb
Related	3N8V 3N8W 3N8Y 3N8Z
Descriptor	Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	cox-1, cyclooxygenase, peroxidase, prostaglandin, heme, nimesulide, merohedral twinned, oxidoreductase
Biological source	Ovis aries (sheep)
Total number of polymer chains	2
Total formula weight	132509.06
Authors	Lee, J.Y. (deposition date: 2010-05-28, release date: 2010-07-28, Last modification date: 2023-09-06)
Primary citation	Sidhu, R.S.,Lee, J.Y.,Yuan, C.,Smith, W.L. Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers Biochemistry, 49:7069-7079, 2010 Cited by PubMed: 20669977 DOI: 10.1021/bi1003298 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation