6NY3
 
 | | CasX ternary complex with 30bp target DNA | | 分子名称: | CasX, DNA Non-target strand, DNA target strand, ... | | 著者 | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | | 登録日 | 2019-02-10 | | 公開日 | 2019-02-27 | | 最終更新日 | 2019-12-25 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
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6NY2
 | | CasX-gRNA-DNA(45bp) state I | | 分子名称: | CasX, DNA Non-target strand, DNA target strand, ... | | 著者 | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | | 登録日 | 2019-02-10 | | 公開日 | 2019-02-27 | | 最終更新日 | 2019-12-25 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
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6NY1
 | | CasX-gRNA-DNA(30bp) State II | | 分子名称: | CasX, DNA Non-target strand, DNA target strand, ... | | 著者 | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | | 登録日 | 2019-02-10 | | 公開日 | 2019-02-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
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6RJ3
 | | Crystal structure of PHGDH in complex with compound 15 | | 分子名称: | 4-[(1~{R})-1-[(2-methyl-5-phenyl-pyrazol-3-yl)carbonylamino]ethyl]benzoic acid, D-3-phosphoglycerate dehydrogenase, SULFATE ION | | 著者 | Bader, G, Wolkerstorfer, B, Zoephel, A. | | 登録日 | 2019-04-26 | | 公開日 | 2019-08-07 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.
J.Med.Chem., 62, 2019
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6RJ6
 | | Crystal structure of PHGDH in complex with BI-4924 | | 分子名称: | 2-[4-[(1~{S})-1-[[4,5-bis(chloranyl)-1,6-dimethyl-indol-2-yl]carbonylamino]-2-oxidanyl-ethyl]phenyl]sulfonylethanoic acid, D-3-phosphoglycerate dehydrogenase | | 著者 | Bader, G, Wolkerstorfer, B, Zoephel, A. | | 登録日 | 2019-04-26 | | 公開日 | 2019-08-07 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.984 Å) | | 主引用文献 | Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.
J.Med.Chem., 62, 2019
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6RJ5
 | | Crystal structure of PHGDH in complex with compound 39 | | 分子名称: | 2-methyl-~{N}-[(1~{R})-1-[4-(methylsulfonylcarbamoyl)phenyl]ethyl]-5-phenyl-pyrazole-3-carboxamide, D-3-phosphoglycerate dehydrogenase, SULFATE ION | | 著者 | Bader, G, Wolkerstorfer, B, Zoephel, A. | | 登録日 | 2019-04-26 | | 公開日 | 2019-08-07 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.
J.Med.Chem., 62, 2019
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6RIH
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6RJ2
 | | Crystal structure of PHGDH in complex with compound 40 | | 分子名称: | D-3-phosphoglycerate dehydrogenase, SULFATE ION, ~{N}-[(1~{R})-1-[4-(ethanoylsulfamoyl)phenyl]ethyl]-2-methyl-5-phenyl-pyrazole-3-carboxamide | | 著者 | Bader, G, Wolkerstorfer, B, Zoephel, A. | | 登録日 | 2019-04-26 | | 公開日 | 2019-08-07 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.
J.Med.Chem., 62, 2019
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6YVX
 | | HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic BB-287 | | 分子名称: | 4-(isoquinolin-3-ylamino)-4-oxobutanoic acid, BICARBONATE ION, Egl nine homolog 1, ... | | 著者 | Chowdhury, R, Banerji, B, Schofield, C.J. | | 登録日 | 2020-04-28 | | 公開日 | 2020-12-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Sci Rep, 10, 2020
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1NIH
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6YW1
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6YW3
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6YVZ
 | | HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic JLS-367 | | 分子名称: | 4-[(5-bromanylisoquinolin-3-yl)amino]-4-oxidanylidene-butanoic acid, BICARBONATE ION, Egl nine homolog 1, ... | | 著者 | Chowdhury, R, Sorensen, J.L, Schofield, C.J. | | 登録日 | 2020-04-29 | | 公開日 | 2020-12-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Sci Rep, 10, 2020
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6YW0
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7ACF
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6YW2
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6YW4
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6CWA
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6G2O
 | | X-ray structure of NSD3-PWWP1 in complex with compound BI-9321 | | 分子名称: | Histone-lysine N-methyltransferase NSD3, [4-[5-(7-fluoranylquinolin-4-yl)-1-methyl-imidazol-4-yl]-3,5-dimethyl-phenyl]methanamine | | 著者 | Boettcher, J, Muellauer, B.J, Weiss-Puxbaum, A, Zoephel, A. | | 登録日 | 2018-03-23 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Nat.Chem.Biol., 15, 2019
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6G27
 | | X-ray structure of NSD3-PWWP1 in complex with compound 5 | | 分子名称: | 5-methyl-6-phenyl-2-piperidin-4-yl-pyridazin-3-one, Histone-lysine N-methyltransferase NSD3 | | 著者 | Boettcher, J, Muellauer, B.J, Weiss-Puxbaum, A, Zoephel, A. | | 登録日 | 2018-03-22 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Nat.Chem.Biol., 15, 2019
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8FYA
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-containing prespacer complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYB
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (17-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYC
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex linear CRISPR repeat conformation | | 分子名称: | Cas1, Cas2-DEDDh, DEDDh, ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FY9
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-deficient prespacer complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER) | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYD
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex bent CRISPR repeat conformation | | 分子名称: | Cas1, Cas2-DEDDh, DNA (13-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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