6RJ5
Crystal structure of PHGDH in complex with compound 39
Summary for 6RJ5
Entry DOI | 10.2210/pdb6rj5/pdb |
Descriptor | D-3-phosphoglycerate dehydrogenase, SULFATE ION, 2-methyl-~{N}-[(1~{R})-1-[4-(methylsulfonylcarbamoyl)phenyl]ethyl]-5-phenyl-pyrazole-3-carboxamide, ... (4 entities in total) |
Functional Keywords | protein-ligand complex, dehydrogenase, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 68306.63 |
Authors | Bader, G.,Wolkerstorfer, B.,Zoephel, A. (deposition date: 2019-04-26, release date: 2019-08-07, Last modification date: 2024-01-24) |
Primary citation | Weinstabl, H.,Treu, M.,Rinnenthal, J.,Zahn, S.K.,Ettmayer, P.,Bader, G.,Dahmann, G.,Kessler, D.,Rumpel, K.,Mischerikow, N.,Savarese, F.,Gerstberger, T.,Mayer, M.,Zoephel, A.,Schnitzer, R.,Sommergruber, W.,Martinelli, P.,Arnhof, H.,Peric-Simov, B.,Hofbauer, K.S.,Garavel, G.,Scherbantin, Y.,Mitzner, S.,Fett, T.N.,Scholz, G.,Bruchhaus, J.,Burkard, M.,Kousek, R.,Ciftci, T.,Sharps, B.,Schrenk, A.,Harrer, C.,Haering, D.,Wolkerstorfer, B.,Zhang, X.,Lv, X.,Du, A.,Li, D.,Li, Y.,Quant, J.,Pearson, M.,McConnell, D.B. Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis. J.Med.Chem., 62:7976-7997, 2019 Cited by PubMed: 31365252DOI: 10.1021/acs.jmedchem.9b00718 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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