6RJ5
Crystal structure of PHGDH in complex with compound 39
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | D-3-phosphoglycerate dehydrogenase | polymer | 314 | 33630.8 | 2 | UniProt (O43175) Pfam (PF00389) Pfam (PF02826) | Homo sapiens (Human) | 3-PGDH,2-oxoglutarate reductase,Malate dehydrogenase |
| 2 | C, E (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D, F (A, B) | 2-methyl-~{N}-[(1~{R})-1-[4-(methylsulfonylcarbamoyl)phenyl]ethyl]-5-phenyl-pyrazole-3-carboxamide | non-polymer | 426.5 | 2 | Chemie (K5N) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 557 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 314 (UniProt: O43175)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
| Met 2 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67261.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1045.1 | |
| All* | Total formula weight | 68306.6 |
