6RJ3

Crystal structure of PHGDH in complex with compound 15

Summary for 6RJ3

Entry DOI	10.2210/pdb6rj3/pdb
Descriptor	D-3-phosphoglycerate dehydrogenase, SULFATE ION, 4-[(1~{R})-1-[(2-methyl-5-phenyl-pyrazol-3-yl)carbonylamino]ethyl]benzoic acid, ... (4 entities in total)
Functional Keywords	protein-ligand complex, dehydrogenase, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	68152.42
Authors	Bader, G.,Wolkerstorfer, B.,Zoephel, A. (deposition date: 2019-04-26, release date: 2019-08-07, Last modification date: 2024-01-24)
Primary citation	Weinstabl, H.,Treu, M.,Rinnenthal, J.,Zahn, S.K.,Ettmayer, P.,Bader, G.,Dahmann, G.,Kessler, D.,Rumpel, K.,Mischerikow, N.,Savarese, F.,Gerstberger, T.,Mayer, M.,Zoephel, A.,Schnitzer, R.,Sommergruber, W.,Martinelli, P.,Arnhof, H.,Peric-Simov, B.,Hofbauer, K.S.,Garavel, G.,Scherbantin, Y.,Mitzner, S.,Fett, T.N.,Scholz, G.,Bruchhaus, J.,Burkard, M.,Kousek, R.,Ciftci, T.,Sharps, B.,Schrenk, A.,Harrer, C.,Haering, D.,Wolkerstorfer, B.,Zhang, X.,Lv, X.,Du, A.,Li, D.,Li, Y.,Quant, J.,Pearson, M.,McConnell, D.B. Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis. J.Med.Chem., 62:7976-7997, 2019 Cited by PubMed: 31365252 DOI: 10.1021/acs.jmedchem.9b00718 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.42 Å)

Structure validation