Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0051287 | molecular_function | NAD binding |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | ARG53 |
| A | SER54 |
| A | ARG74 |
| A | HOH592 |
| A | HOH596 |
| B | ARG134 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue K58 A 402 |
| Chain | Residue |
| A | PRO175 |
| A | ILE176 |
| A | ILE177 |
| A | HIS205 |
| A | THR206 |
| A | PRO207 |
| A | THR212 |
| A | LEU215 |
| A | HOH530 |
| A | HOH558 |
| A | HOH580 |
| A | HOH582 |
| A | HOH618 |
| A | HOH677 |
| A | HOH686 |
| A | GLY151 |
| A | TYR173 |
| A | ASP174 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| A | ARG134 |
| B | ARG53 |
| B | SER54 |
| B | ARG74 |
| B | ALA285 |
| B | HOH515 |
| B | HOH536 |
| B | HOH543 |
| B | HOH648 |
| B | HOH658 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue K58 B 402 |
| Chain | Residue |
| B | TYR173 |
| B | ASP174 |
| B | PRO175 |
| B | ILE176 |
| B | HIS205 |
| B | THR206 |
| B | PRO207 |
| B | LEU209 |
| B | LEU215 |
| B | HOH530 |
| B | HOH533 |
| B | HOH572 |
| B | HOH597 |
| B | HOH667 |
| B | HOH672 |
Functional Information from PROSITE/UniProt
| site_id | PS00065 |
| Number of Residues | 28 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. LGILGlGRIGrevatrmqsfgmk.TIgYD |
| Chain | Residue | Details |
| A | LEU147-ASP174 | |
| site_id | PS00670 |
| Number of Residues | 23 |
| Details | D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. IWplCDFItVHtPllpsTtgLlN |
| Chain | Residue | Details |
| A | ILE195-ASN217 | |
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. CKkGvRVVNcARGgIVD |
| Chain | Residue | Details |
| A | CYS224-ASP240 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | ARG235 | |
| B | ARG235 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU264 | |
| B | GLU264 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor |
| Chain | Residue | Details |
| A | HIS282 | |
| B | HIS282 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|Ref.21 |
| Chain | Residue | Details |
| A | THR77 | |
| B | ASP174 | |
| B | THR206 | |
| B | CYS233 | |
| B | ASP259 | |
| B | HIS282 | |
| A | ARG154 | |
| A | ASP174 | |
| A | THR206 | |
| A | CYS233 | |
| A | ASP259 | |
| A | HIS282 | |
| B | THR77 | |
| B | ARG154 | |
| Chain | Residue | Details |
| A | SER13 | |
| B | SER13 | |
| Chain | Residue | Details |
| A | LYS20 | |
| B | LYS20 | |
| Chain | Residue | Details |
| A | LYS57 | |
| B | LYS57 | |
| Chain | Residue | Details |
| A | THR77 | |
| B | THR77 | |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| A | LYS20 | |
| B | LYS20 | |
