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6RIH

Crystal structure of PHGDH in complex with compound 9

Summary for 6RIH
Entry DOI10.2210/pdb6rih/pdb
DescriptorD-3-phosphoglycerate dehydrogenase, ~{N}-cyclopropyl-2-methyl-5-phenyl-pyrazole-3-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywordsprotein-ligand complex, dehydrogenase, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight67840.16
Authors
Bader, G.,Wolkerstorfer, B.,Zoephel, A. (deposition date: 2019-04-24, release date: 2019-08-07, Last modification date: 2024-01-24)
Primary citationWeinstabl, H.,Treu, M.,Rinnenthal, J.,Zahn, S.K.,Ettmayer, P.,Bader, G.,Dahmann, G.,Kessler, D.,Rumpel, K.,Mischerikow, N.,Savarese, F.,Gerstberger, T.,Mayer, M.,Zoephel, A.,Schnitzer, R.,Sommergruber, W.,Martinelli, P.,Arnhof, H.,Peric-Simov, B.,Hofbauer, K.S.,Garavel, G.,Scherbantin, Y.,Mitzner, S.,Fett, T.N.,Scholz, G.,Bruchhaus, J.,Burkard, M.,Kousek, R.,Ciftci, T.,Sharps, B.,Schrenk, A.,Harrer, C.,Haering, D.,Wolkerstorfer, B.,Zhang, X.,Lv, X.,Du, A.,Li, D.,Li, Y.,Quant, J.,Pearson, M.,McConnell, D.B.
Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.
J.Med.Chem., 62:7976-7997, 2019
Cited by
PubMed: 31365252
DOI: 10.1021/acs.jmedchem.9b00718
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

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