9DPF
| Crystal structure of TMPRSS11D S368A complexed with its own zymogen activation motif | 分子名称: | 1,2-ETHANEDIOL, Transmembrane protease serine 11D, Transmembrane protease serine 11D non-catalytic chain | 著者 | Fraser, B.J, Dong, A, Ilyassov, O, Seitova, A, Li, Y, Edwards, A, Benard, F, Arrowsmith, C, Structural Genomics Consortium (SGC) | 登録日 | 2024-09-21 | 公開日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of TMPRSS11D S368A complexed with its own zymogen activation motif To Be Published
|
|
9DTB
| Crystal structure of the WDR domain of WDR91 in complex with DR3460 | 分子名称: | N-[(1R)-4-cyano-2,3-dihydro-1H-inden-1-yl]-4-[(quinazolin-4-yl)amino]benzamide, UNKNOWN ATOM OR ION, WD repeat-containing protein 91 | 著者 | Zeng, H, Ahmad, H, Dong, A, Seitova, A, Counago, R.M, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2024-09-30 | 公開日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Crystal structure of the WDR domain of WDR91 in complex with DR3460 To be published
|
|
9DTA
| Crystal structure of the WDR domain of WDR91 in complex with DR3448 | 分子名称: | N-(1-benzoyl-1,2,3,4-tetrahydroquinolin-6-yl)-2-(3-cyano-2-methoxyphenyl)acetamide, WD repeat-containing protein 91 | 著者 | Zeng, H, Ahmad, H, Dong, A, Seitova, A, Counago, R.M, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2024-09-30 | 公開日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of the WDR domain of WDR91 in complex with DR3448 To be published
|
|
8SAH
| Huntingtin C-HEAT domain in complex with HAP40 | 分子名称: | 40-kDa huntingtin-associated protein, Huntingtin | 著者 | Harding, R.J, Deme, J.C, Alteen, M.G, Arrowsmith, C.H, Lea, S.M, Structural Genomics Consortium (SGC) | 登録日 | 2023-03-31 | 公開日 | 2023-04-26 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40. Structure, 31, 2023
|
|
5HZM
| Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae) | 分子名称: | Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN ATOM OR ION | 著者 | DONG, A, ZENG, H, WALKER, J.R, Seitova, A, Hutchinson, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, MIN, J, WU, H, Structural Genomics Consortium (SGC) | 登録日 | 2016-02-02 | 公開日 | 2016-02-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structural basis of arginine asymmetrical dimethylation by PRMT6. Biochem. J., 473, 2016
|
|
3UR4
| Crystal structure of human WD repeat domain 5 with compound | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ... | 著者 | Dong, A, Dombrovski, L, Senisterra, G, Wernimont, A, Wasney, G.A, Allali Hassani, A, Nguyen, K.T, Smil, D, Bolshan, Y, Hajian, T, Poda, G, Chau, I, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-11-21 | 公開日 | 2011-12-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449, 2013
|
|
6X9O
| High resolution cryoEM structure of huntingtin in complex with HAP40 | 分子名称: | 40-kDa huntingtin-associated protein, Huntingtin | 著者 | Harding, R.J, Deme, J.C, Lea, S.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | 登録日 | 2020-06-03 | 公開日 | 2020-06-17 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1. Commun Biol, 4, 2021
|
|
4EBB
| Structure of DPP2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 2, ZINC ION | 著者 | Shewchuk, L.M, Hassell, A.H, Sweitzer, S.M, Sweitzer, T.D, McDevitt, P.J, Kennedy-Wilson, K.M, Johanson, K.O. | 登録日 | 2012-03-23 | 公開日 | 2012-09-19 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of Human DPP7 Reveal the Molecular Basis of Specific Inhibition and the Architectural Diversity of Proline-Specific Peptidases. Plos One, 7, 2012
|
|
3SMR
| Crystal structure of human WD repeat domain 5 with compound | 分子名称: | 1,2-ETHANEDIOL, 2-chloro-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ... | 著者 | Dong, A, Dombrovski, L, Wasney, G.A, Tempel, W, Senisterra, G, Bolshan, Y, Smil, D, Nguyen, K.T, Hajian, T, Poda, G, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Brown, P.J, Schapira, M, Arrowsmith, C.H, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-06-28 | 公開日 | 2011-08-31 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449, 2013
|
|
4MI0
| Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2) | 分子名称: | Histone-lysine N-methyltransferase EZH2, UNKNOWN ATOM OR ION, ZINC ION | 著者 | Dong, A, Zeng, H, He, H, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2013-08-30 | 公開日 | 2013-09-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. Plos One, 8, 2013
|
|
4I79
| Crystal structure of human NUP43 | 分子名称: | Nucleoporin Nup43, UNKNOWN ATOM OR ION, floating chain, ... | 著者 | Xu, C, Tempel, W, Li, Z, He, H, Wernimont, A.K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2012-11-30 | 公開日 | 2013-02-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structure of human nuclear pore complex component NUP43. Febs Lett., 589, 2015
|
|
2ITJ
| |
7SSE
| Crystal structure of the WDR domain of human DCAF1 in complex with CYCA-117-70 | 分子名称: | DDB1- and CUL4-associated factor 1, N-[(3R)-1-(3-fluorophenyl)piperidin-3-yl]-6-(morpholin-4-yl)pyrimidin-4-amine | 著者 | Kimani, S, Owen, J, Li, A, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Shahani, V.M, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2021-11-10 | 公開日 | 2021-12-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Discovery of a Novel DCAF1 Ligand Using a Drug-Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets. J.Chem.Inf.Model., 63, 2023
|
|
2IPR
| |
5E8R
| Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae) | 分子名称: | CHLORIDE ION, N-methyl-N-({4-[4-(propan-2-yloxy)phenyl]-1H-pyrrol-3-yl}methyl)ethane-1,2-diamine, Protein arginine N-methyltransferase 6, ... | 著者 | DONG, A, ZENG, H, LIU, J, TEMPEL, W, Seitova, A, Hutchinson, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, JIN, J, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | 登録日 | 2015-10-14 | 公開日 | 2015-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. Acs Chem.Biol., 11, 2016
|
|
2NL8
| |
7UFV
| Crystal structure of the WDR domain of human DCAF1 in complex with OICR-6766 | 分子名称: | (3P)-N-[(1S)-3-amino-1-(3-chlorophenyl)-3-oxopropyl]-3-(2-fluorophenyl)-1H-pyrazole-4-carboxamide, DDB1- and CUL4-associated factor 1, UNKNOWN ATOM OR ION | 著者 | Kimani, S, Li, A, Li, Y, Dong, A, Hutchinson, A, Seitova, A, Wilson, B, Al-Awar, R, Vedadi, M, Brown, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2022-03-23 | 公開日 | 2022-05-04 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of Nanomolar DCAF1 Small Molecule Ligands. J.Med.Chem., 66, 2023
|
|
2PVS
| Structure of human pancreatic lipase related protein 2 mutant N336Q | 分子名称: | CALCIUM ION, Pancreatic lipase-related protein 2, SULFATE ION | 著者 | Spinelli, S, Eydoux, C, Carriere, F, Cambillau, C. | 登録日 | 2007-05-10 | 公開日 | 2007-12-18 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation. Biochemistry, 47, 2008
|
|
5E16
| Co-crystal structure of the N-termial cGMP binding domain of Plasmodium falciparum PKG with cGMP | 分子名称: | CGMP-dependent protein kinase, CYCLIC GUANOSINE MONOPHOSPHATE | 著者 | El Bakkouri, M, Walker, J.R, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Structural Genomics Consortium (SGC) | 登録日 | 2015-09-29 | 公開日 | 2015-11-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6W6D
| Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with SGC6870 inhibitor | 分子名称: | (5R)-4-(5-bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one, Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Halabelian, L, Zeng, H, Dong, A, Jin, J, Shen, Y, Kaniskan, H.U, Hutchinson, A, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2020-03-16 | 公開日 | 2020-04-29 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. J.Med.Chem., 64, 2021
|
|
5WCJ
| Crystal Structure of Human Methyltransferase-like protein 13 in complex with SAH | 分子名称: | Methyltransferase-like protein 13, S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN ATOM OR ION | 著者 | Halabelian, L, Loppnau, P, Seitova, A, Hutchinson, A, Hunt, B, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | 登録日 | 2017-06-30 | 公開日 | 2017-07-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates. Nat Commun, 9, 2018
|
|
6OGN
| Crystal structure of mouse protein arginine methyltransferase 7 in complex with SGC8158 chemical probe | 分子名称: | 5'-S-(4-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}butyl)-5'-thioadenosine, Protein arginine N-methyltransferase 7, UNKNOWN ATOM OR ION, ... | 著者 | Halabelian, L, Dong, A, Zeng, H, Li, Y, Hutchinson, A, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | 登録日 | 2019-04-03 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nat Commun, 11, 2020
|
|
6P7I
| Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Compound | 分子名称: | GLYCEROL, N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]prop-2-enamide, N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]propanamide, ... | 著者 | Halabelian, L, Dong, A, Zeng, H, Li, Y, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2019-06-05 | 公開日 | 2019-06-26 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor J.Med.Chem., 63, 2020
|
|
3C8X
| Crystal structure of the ligand binding domain of human Ephrin A2 (Epha2) receptor protein kinase | 分子名称: | Ephrin type-A receptor 2 | 著者 | Walker, J.R, Yermekbayeva, L, Seitova, A, Butler-Cole, C, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2008-02-14 | 公開日 | 2008-03-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Architecture of Eph receptor clusters. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
3CZU
| Crystal structure of the human ephrin A2- ephrin A1 complex | 分子名称: | Ephrin type-A receptor 2, Ephrin-A1, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Walker, J.R, Yermekbayeva, L, Seitova, A, Butler-Cole, C, Bountra, C, Wikstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2008-04-30 | 公開日 | 2008-08-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Architecture of Eph receptor clusters. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|