8SAH

Huntingtin C-HEAT domain in complex with HAP40

Summary for 8SAH

• Entry DOI: 10.2210/pdb8sah/pdb
• EMDB information: 28766
• Descriptor: Huntingtin, 40-kDa huntingtin-associated protein (2 entities in total)
• Functional Keywords: huntingtin, scaffold, heat repeats, structural genomics, structural genomics consortium, sgc, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 158822.01

Authors

Harding, R.J.,Deme, J.C.,Alteen, M.G.,Arrowsmith, C.H.,Lea, S.M.,Structural Genomics Consortium (SGC) (deposition date: 2023-03-31, release date: 2023-04-26, Last modification date: 2023-09-20)

• Primary citation: Alteen, M.G.,Deme, J.C.,Alvarez, C.P.,Loppnau, P.,Hutchinson, A.,Seitova, A.,Chandrasekaran, R.,Silva Ramos, E.,Secker, C.,Alqazzaz, M.,Wanker, E.E.,Lea, S.M.,Arrowsmith, C.H.,Harding, R.J.; Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.; Structure, 31:1121-1131.e6, 2023; PubMed: 37390814; DOI: 10.1016/j.str.2023.06.002

Experimental method

ELECTRON MICROSCOPY (3.2 Å)