8SAH

Huntingtin C-HEAT domain in complex with HAP40

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Huntingtin	polymer	1057	117479.8	1	UniProt (P42858) Pfam (PF20927)	Homo sapiens (human)	Huntington disease protein,HD protein
2	B (B)	40-kDa huntingtin-associated protein	polymer	389	41342.3	1	UniProt (P23610)	Homo sapiens (human)	HAP40,CpG island protein,Factor VIII intron 22 protein

Sequence modifications

A: 2095 - 3138 (UniProt: P42858)

PDB	External Database	Details
Met 2094	-	initiating methionine
His 2311	Tyr 2309	variant
Ile 2788	Val 2786	variant
Gly 3139	-	expression tag
Gly 3140	-	expression tag
Ser 3141	-	expression tag
Gly 3142	-	expression tag
Asp 3143	-	expression tag
Tyr 3144	-	expression tag
Lys 3145	-	expression tag
Asp 3146	-	expression tag
Asp 3147	-	expression tag
Asp 3148	-	expression tag
Asp 3149	-	expression tag
Lys 3150	-	expression tag

B: 1 - 371 (UniProt: P23610)

PDB	External Database	Details
Met -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Arg -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	158822.0
All*	Total formula weight	158822.0

*Water molecules are not included.