6X9O

High resolution cryoEM structure of huntingtin in complex with HAP40

Summary for 6X9O

• Entry DOI: 10.2210/pdb6x9o/pdb
• EMDB information: 22106
• Descriptor: Huntingtin, 40-kDa huntingtin-associated protein (2 entities in total)
• Functional Keywords: huntingtin, htt, 40-kda huntingtin-associated protein, hap40, structural genomics, structural genomics consortium, sgc, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 390814.60

Authors

Harding, R.J.,Deme, J.C.,Lea, S.M.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC) (deposition date: 2020-06-03, release date: 2020-06-17, Last modification date: 2022-03-30)

• Primary citation: Harding, R.J.,Deme, J.C.,Hevler, J.F.,Tamara, S.,Lemak, A.,Cantle, J.P.,Szewczyk, M.M.,Begeja, N.,Goss, S.,Zuo, X.,Loppnau, P.,Seitova, A.,Hutchinson, A.,Fan, L.,Truant, R.,Schapira, M.,Carroll, J.B.,Heck, A.J.R.,Lea, S.M.,Arrowsmith, C.H.; Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1.; Commun Biol, 4:1374-1374, 2021; PubMed: 34880419; DOI: 10.1038/s42003-021-02895-4

Experimental method

ELECTRON MICROSCOPY (2.6 Å)